Anethole Ameliorates Acetic Acid-Induced Colitis in Mice: Anti-Inflammatory and Antioxidant Effects
April 2022
in “
Evidence-based Complementary and Alternative Medicine
”
Studysummary This study found that anethole reduced oxidative stress and inflammation in acetic acid-induced colitis in mice, suggesting protective effects in this experimental setting.
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The study on 48 male NMRI mice found that anethole effectively reduced symptoms of acetic acid-induced colitis by mitigating histopathological changes and enhancing antioxidant activity. Anethole increased total antioxidant capacity and decreased malondialdehyde levels, while also reducing the expression of inflammatory genes such as TNF-α, IL-1β, and TLR4. These results suggested that anethole had potential anti-inflammatory and antioxidant effects, which could be beneficial in managing colitis, though further research was needed to understand the underlying mechanisms.
