Flavonoids as Potential Wound-Healing Molecules: Emphasis on Pathways Perspective

    February 2023 in “ International Journal of Molecular Sciences ”
    Nabilah Zulkefli, Che Nur Mazadillina Che Zahari, Nor Hafiza Sayuti, Ammar Akram Kamarudin, Norazalina Saad, Hamizah Shahirah Hamezah, Hamidun Bunawan, Syarul Nataqain Baharum, Ahmed Mediani, Qamar Uddin Ahmed, Ahmad Fahmi Harun Ismail, Murni Nazira Sarian
    TLDR Flavonoids can help heal wounds effectively due to their beneficial properties.
    The document reviews the potential of flavonoids as wound-healing agents, emphasizing their anti-inflammatory, antioxidant, and pro-collagen properties. Flavonoids, found in fruits and vegetables, can influence wound healing through various pathways, such as Wnt/β-catenin, TGF-β, and NF-κB, which are crucial for tissue remodeling and inflammation regulation. Clinical trials have shown promising results, with quercetin improving wound healing in diabetes patients and a combination of flavonoids accelerating venous leg ulcer healing. Despite these findings, further research is needed to fully understand their mechanisms and optimize their therapeutic use, especially in integrating advanced technologies like nanotechnology. The review highlights the need for natural-product-based treatments due to the limitations of conventional drugs and the growing global chronic wound care market.
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