Dual-Action Icariin-Containing Thermosensitive Hydrogel for Wound Macrophage Polarization and Hair Follicle Neogenesis

    Ying-Ying Teng, Ming-Li Zou, Siyu Liu … Feng-Lai Yuan
    Studysummary This study found that a hydrogel containing icariin enhanced wound healing and hair-follicle regeneration in vivo by promoting M2 macrophage polarization and modulating the BMP pathway, with treated skin defects showing improved recovery and new hair follicle development compared to untreated defects.
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    Research cited in this study 19

    1. Pyridoxine Regulates Hair Follicle Development via the PI3K/Akt, Wnt, and Notch Signalling Pathways in Rex Rabbits Animal nutrition · 2021
    2. Macrophage Related Chronic Inflammation in Non-Healing Wounds Frontiers in Immunology · 2021
    3. Back to the Future: From Appendage Development Toward Future Human Hair Follicle Neogenesis Frontiers in Cell and Developmental Biology · 2021
    4. An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities Frontiers in Cell and Developmental Biology · 2020
    5. Regeneration of Dermis: Scarring and Cells Involved Cells · 2019
    6. Engineering Pro-Regenerative Hydrogels for Scarless Wound Healing Advanced Healthcare Materials · 2018
    7. Production-Scale Fibronectin Nanofibers Promote Wound Closure and Tissue Repair in a Dermal Mouse Model Biomaterials · 2018
    8. Establishment and Characterization of Five Immortalized Human Scalp Dermal Papilla Cell Lines Biochemical and Biophysical Research Communications · 2018
    9. Tissue Engineering of Skin and Regenerative Medicine for Wound Care Burns & Trauma · 2018
    10. Dermal Fibroblasts in Cutaneous Development and Healing Wiley Interdisciplinary Reviews-Developmental Biology · 2017
    11. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    12. A Conditioned Medium of Umbilical Cord Mesenchymal Stem Cells Overexpressing Wnt7a Promotes Wound Repair and Regeneration of Hair Follicles in Mice Stem Cells International · 2017
    13. Hair Follicles’ Transit-Amplifying Cells Govern Concurrent Dermal Adipocyte Production Through Sonic Hedgehog Genes & Development · 2016
    14. Wound Healing and Skin Regeneration Cold Spring Harbor Perspectives in Medicine · 2015
    15. Advances in a Rapidly Emerging Field of Hair Follicle Stem Cell Research PubMed · 2014
    16. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    17. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    18. BMP Signaling in the Control of Skin Development and Hair Follicle Growth Differentiation · 2004
    19. Regulation of PDGF and PDGF Receptor in Cultured Dermal Papilla Cells and Follicular Keratinocytes of the Human Hair Follicle Experimental Dermatology · 2003

    Related research 7

    1. Wound-Induced Hair Neogenesis: A Portal to the Development of New Therapies for Hair Loss and Wound Regeneration Cold Spring Harbor Perspectives in Biology · 2022
    2. Dual-Action Icariin-Containing Thermosensitive Hydrogel for Wound Macrophage Polarization and Hair Follicle Neogenesis Frontiers in Bioengineering and Biotechnology · 2022
    3. 4-Aminopyridine Promotes Accelerated Skin Wound Healing via Neurogenic-Mediator Expression bioRxiv (Cold Spring Harbor Laboratory) · 2021
    4. Treatment of Full-Thickness Skin Wounds with Blood-Derived CD34+ Precursor Cells Enhances Healing with Hair Follicle Regeneration Advances in wound care · 2019
    5. Activation of Nrf2 Promotes Wound Healing by Expansion of Hair Follicle Stem Cell Populations Journal of Investigative Dermatology · 2017
    6. Epigenetic Control of Skin and Hair Regeneration After Wounding Experimental Dermatology · 2014
    7. Histological and Immunohistochemical Studies of Excisional Wounds in Rats: The Role of Hair Follicles in Wound Healing Durham e-Theses (Durham University) · 2000