4-Aminopyridine Promotes Accelerated Skin Wound Healing via Neurogenic-Mediator Expression

    November 2021 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Jagadeeshaprasad Mashanipalya Guddadarangaiah, Prem Kumar Govindappa, Amanda M. Nelson, Mark David Noble, John C. Elfar
    Image of study
    TLDR 4-aminopyridine helps skin wounds heal faster and better.
    The study found that 4-aminopyridine (4-AP), a potassium channel blocker approved by the FDA for improving walking ability in multiple sclerosis, significantly enhances skin wound healing. The benefits of 4-AP include faster wound closure, restoration of normal skin architecture, increased vascularization, reinnervation, and hair follicle neogenesis within the healed wounds. The compound also increased levels of vimentin (fibroblasts), α-smooth muscle actin (collagen-producing myofibroblasts), and neuronal regeneration. Additionally, 4-AP increased the expression of SRY-Box Transcription Factor 10 (SOX10) and levels of transforming growth factor-β (TGF-β), substance P, and nerve growth factor (NGF), which are important promoters of wound healing. In-vitro studies showed that 4-AP enhanced the proliferation and migration of human keratinocytes and Schwann cells, and improved cellular interactions between neuronal and non-neuronal cells to further accelerate wound healing. Therefore, 4-AP could be a promising new approach to enhance skin wound healing and tissue regeneration.
    Discuss this study in the Community →

    Research cited in this study

    7 / 7 results

    Related Community Posts Join

    6 / 1000+ results

      community 4 months min/dut/needling Norwood 6

      in Progress Pictures  13 upvotes 1 week ago
      The user is using oral Minoxidil, oral Dutasteride, microneedling, and RU58841 for hair loss, noticing slow progress with small hairs appearing. They are inconsistent with microneedling frequency, sometimes doing it weekly or skipping weeks.

      community 4 months of restarting treatment. M36

      in Progress Pictures  58 upvotes 2 weeks ago
      A 36-year-old man restarted hair loss treatment after a break, using topical Minoxidil 5% twice daily, topical Finasteride 0.01% daily, and Ketoconazole 2% three times a week, along with supplements like Vitamin B12, D3, C, Biotin, Omega-3, zinc, and copper. He avoids oral Finasteride due to side effects and plans to evaluate progress after a year.

      community 4.5 Months on 0,25 Finasteride only | 23M

      in Progress Pictures  37 upvotes 3 weeks ago
      A 23-year-old male has been using 0.25mg finasteride daily for 4.5 months to address early-stage male pattern baldness, with positive results and no significant side effects. He plans to continue with this dosage and may consider increasing it or adding minoxidil if necessary.

    Related Research

    2 / 2 results