4-Aminopyridine Promotes Accelerated Skin Wound Healing via Neurogenic-Mediator Expression

    November 2021 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Jagadeeshaprasad Mashanipalya Guddadarangaiah, Prem Kumar Govindappa, Amanda M. Nelson, Mark David Noble, John C. Elfar
    Image of study
    TLDR 4-aminopyridine helps skin wounds heal faster and better.
    The study found that 4-aminopyridine (4-AP), a potassium channel blocker approved by the FDA for improving walking ability in multiple sclerosis, significantly enhances skin wound healing. The benefits of 4-AP include faster wound closure, restoration of normal skin architecture, increased vascularization, reinnervation, and hair follicle neogenesis within the healed wounds. The compound also increased levels of vimentin (fibroblasts), α-smooth muscle actin (collagen-producing myofibroblasts), and neuronal regeneration. Additionally, 4-AP increased the expression of SRY-Box Transcription Factor 10 (SOX10) and levels of transforming growth factor-β (TGF-β), substance P, and nerve growth factor (NGF), which are important promoters of wound healing. In-vitro studies showed that 4-AP enhanced the proliferation and migration of human keratinocytes and Schwann cells, and improved cellular interactions between neuronal and non-neuronal cells to further accelerate wound healing. Therefore, 4-AP could be a promising new approach to enhance skin wound healing and tissue regeneration.
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    6 / 1000+ results

      community 4 months .5 Dut and 3 months 2.5 Minox update

      in Progress Pictures  24 upvotes 5 days ago
      The user reports positive results from using 0.5 mg dutasteride daily for four months and 2.5 mg oral minoxidil for three months, with no side effects. They switched from topical minoxidil to this oral combination.

      community 4 days after a hair transplant

      in Satire  1457 upvotes 1 week ago
      A satirical discussion about a hair transplant, with humorous comments on graft placement and clinic choice. The conversation includes references to a "Rebuild a Scalp Clinic" and jokes about using pubic hair and overharvesting.

      community 4 years progress- Minox combined with Fin

      in Progress Pictures  198 upvotes 1 month ago
      A user shared their 4-year progress using topical minoxidil and 1mg finasteride daily for hair regrowth, noting plans to reduce finasteride due to minor side effects. They emphasized consistency as key to success, with noticeable improvements in hair density and color.

    Related Research

    2 / 2 results