4-Aminopyridine Promotes Accelerated Skin Wound Healing via Neurogenic-Mediator Expression

    Jagadeeshaprasad Mashanipalya Guddadarangaiah, Prem Kumar Govindappa, Amanda M. Nelson … John C. Elfar

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that 4-aminopyridine, a potassium channel blocker, greatly improves skin wound healing by accelerating wound closure, enhancing tissue regeneration, and promoting hair follicle neogenesis.
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    Research cited in this study 7

    1. Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells Cell · 2020
    2. Epidermal Stem Cells in Wound Healing and Their Clinical Applications Stem Cell Research & Therapy · 2019
    3. Wound Healing: A Cellular Perspective Physiological Reviews · 2018
    4. dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration Cell Stem Cell · 2015
    5. Keratin K15 as a Biomarker of Epidermal Stem Cells International Journal of Molecular Sciences · 2013
    6. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    7. Keratin 17 Modulates Hair Follicle Cycling in a TNFα-Dependent Fashion Genes & Development · 2006

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