4-Aminopyridine Promotes Accelerated Skin Wound Healing via Neurogenic-Mediator Expression

    November 2021 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Jagadeeshaprasad Mashanipalya Guddadarangaiah, Prem Kumar Govindappa, Amanda M. Nelson, Mark David Noble, John C. Elfar
    Image of study
    TLDR 4-aminopyridine helps skin wounds heal faster and better.
    The study found that 4-aminopyridine (4-AP), a potassium channel blocker approved by the FDA for improving walking ability in multiple sclerosis, significantly enhances skin wound healing. The benefits of 4-AP include faster wound closure, restoration of normal skin architecture, increased vascularization, reinnervation, and hair follicle neogenesis within the healed wounds. The compound also increased levels of vimentin (fibroblasts), α-smooth muscle actin (collagen-producing myofibroblasts), and neuronal regeneration. Additionally, 4-AP increased the expression of SRY-Box Transcription Factor 10 (SOX10) and levels of transforming growth factor-β (TGF-β), substance P, and nerve growth factor (NGF), which are important promoters of wound healing. In-vitro studies showed that 4-AP enhanced the proliferation and migration of human keratinocytes and Schwann cells, and improved cellular interactions between neuronal and non-neuronal cells to further accelerate wound healing. Therefore, 4-AP could be a promising new approach to enhance skin wound healing and tissue regeneration.
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    6 / 1000+ results

      community 4 Months (Fin + Duta + Minoxidil + Micro)

      in Progress Pictures  265 upvotes 5 days ago
      The conversation discusses a hair loss treatment regimen including finasteride, dutasteride, minoxidil, tretinoin, microneedling, and red light therapy. The user plans to update on progress after eight months.

      community 4 months!! We making progress!!

      in Progress Pictures  474 upvotes 1 week ago
      A user shared their successful hair regrowth journey using 0.5 mg Dutasteride, 2.5 mg oral Minoxidil, and Biotin gummies, after switching from Finasteride due to insomnia. They highlighted the importance of brushing the scalp for blood flow and reported significant progress in four months without side effects.
      [object Object]

      community 4 months on dut and topical min as a 23 year old

      in Progress Pictures  80 upvotes 1 week ago
      A 23-year-old shares progress in hair quality after 4 months using dutasteride, topical minoxidil, and other treatments, noting improved crown thickness but persistent temple thinning. They switched from finasteride to dutasteride due to side effects and started testosterone replacement therapy, which they believe helps mitigate side effects.

      community 4 month progress. Oral fin and topical min

      in Progress Pictures  1432 upvotes 2 weeks ago
      A user shared their 4-month hair regrowth progress using oral finasteride and topical minoxidil, reporting no side effects and positive feedback on their appearance. The post sparked debate, with many users doubting the authenticity of the photos, while others congratulated the user on their impressive results.

      community 4 weeks in oral Minoxidil & Dut

      in Is this regrowth?  164 upvotes 3 weeks ago
      The conversation is about a user experiencing small hair regrowth after 4 weeks of using oral Minoxidil and Dutasteride, and considering a future FUE transplant. Some users express skepticism about the regrowth, while others share similar experiences or doubts about the effectiveness of the treatment.

      community 4 months apart (aug 15 - dec 19)

      in Progress Pictures  538 upvotes 3 weeks ago
      The user shared progress pictures showing hair improvement over four months using 1 mg finasteride and 5 mg minoxidil daily. They reported no significant side effects and plan to reduce the minoxidil dose once satisfied with the results.

    Related Research

    2 / 2 results