Flavonoids with Two Hydroxyl Groups in the B-Ring Promote Pigmented Hair Regeneration

The study from 2019 found that flavonoids with two hydroxyl groups in the B-ring, specifically sterubin, luteolin, and hydroxygenkwanin, effectively promoted the regeneration of black pigmented hair in mice after skin wounding. Flavonoids with only one OH group in the B-ring were not effective. The study suggests that the chemical structure of flavonoids is crucial for their ability to induce pigmented hair regeneration following skin injury. The experiments included a control group of 44 mice and treatment groups with 17 to 21 mice each.