Curcumin-Based Nanoformulations Alleviate Wounds And Related Disorders: A Comprehensive Review
March 2023
in “
BioFactors
”
Studysummary This study describes how incorporating curcumin-loaded nanoparticles into various nanoformulations can enhance its bioavailability and improve wound healing processes such as angiogenesis, collagen deposition, and cell proliferation.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
Curcumin's low solubility and bioavailability limit its effectiveness as a free drug, but incorporating it into nanoformulations significantly enhances its therapeutic potential for wound healing. These nanoformulations, including nanofibers, nanoparticles, nanosprays, and others, improve bioavailability and promote processes like angiogenesis, collagen deposition, and fibroblast proliferation. Controlled-release nanoformulations ensure sustained presence of curcumin at the wound site, with systems like CUR-loaded chitosan nanoparticles in nanofibers extending release time to 240 hours. Additionally, porous structures such as sponges and hydrogels mimic the extracellular matrix, supporting cell attachment and nutrient flow, which are crucial for effective wound healing. The study highlights the promise of curcumin-based nanoformulations in enhancing wound treatment outcomes.
