A Compositionally Synergistic Approach for the Development of a Multifunctional Bilayer Scaffold with Antibacterial Property for Infected and Chronic Wounds
May 2021
in “
Chemical Engineering Journal
”
curcumin dextran nanoparticles cerium oxide nanoparticles gelatin cryogel polyvinyl alcohol poly (vinyl pyrrolidone) iodine potassium iodide electrospun fibrous layer antibacterial activity antioxidant activity wound closure hair growth collagen deposition curcumin cerium oxide gelatin PVA PVP fibrous layer antibacterial antioxidant wound healing hair regrowth collagen
TLDR The developed scaffold effectively treats chronic wounds by promoting healing and preventing infection.
The study developed a multifunctional bilayer scaffold using cryogelation and electrospinning techniques to treat chronic wounds. The scaffold, composed of curcumin dextran nanoparticles and cerium oxide nanoparticles in a gelatin cryogel layer, and a polyvinyl alcohol-poly (vinyl pyrrolidone)-iodine-potassium iodide electrospun fibrous layer, showed high water uptake, degradation, hemocompatibility, and sustained release of active components. In-vitro studies demonstrated enhanced cell viability, migration, and strong antioxidant and antibacterial activity. In-vivo models showed faster wound closure, infection prevention, and efficient healing with mature epithelialization, hair growth, and collagen deposition, suggesting its potential for advanced wound dressing applications.