A Compositionally Synergistic Approach for the Development of a Multifunctional Bilayer Scaffold with Antibacterial Property for Infected and Chronic Wounds

    May 2021 in “ Chemical Engineering Journal ”
    Syed Muntazir Andrabi, Prerna Singh, S. B. Majumder, Ashok Kumar
    TLDR The developed scaffold effectively treats chronic wounds by promoting healing and preventing infection.
    The study developed a multifunctional bilayer scaffold for chronic wound healing using a novel design combining cryogelation and electrospinning techniques. The scaffold consisted of a lower gelatin-based cryogel layer and a top PVA-PVP-I-KI electrospun layer. The cryogel layer incorporated curcumin-amphiphilic dextran nanoparticles and CeO2 nanoparticles, providing anti-inflammatory and antioxidant properties, while the electrospun layer ensured prolonged antibacterial activity through sustained iodine release. The scaffold's macroporous structure facilitated cell infiltration and proliferation, reducing inflammation and regulating ROS levels. The bilayer system demonstrated significant multifunctional properties, promoting successful healing of chronic wounds in both in-vitro and in-vivo studies.
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