A Compositionally Synergistic Approach for the Development of a Multifunctional Bilayer Scaffold with Antibacterial Property for Infected and Chronic Wounds
May 2021
in “
Chemical Engineering Journal
”
curcumin dextran nanoparticles cerium oxide nanoparticles gelatin cryogel polyvinyl alcohol poly (vinyl pyrrolidone) iodine potassium iodide electrospun fibrous layer antibacterial activity antioxidant activity wound closure hair growth collagen deposition curcumin cerium oxide gelatin PVA PVP fibrous layer antibacterial antioxidant wound healing hair regrowth collagen
TLDR The developed scaffold effectively treats chronic wounds by promoting healing and preventing infection.
The study developed a multifunctional bilayer scaffold for chronic wound healing using a novel design combining cryogelation and electrospinning techniques. The scaffold consisted of a lower gelatin-based cryogel layer and a top PVA-PVP-I-KI electrospun layer. The cryogel layer incorporated curcumin-amphiphilic dextran nanoparticles and CeO2 nanoparticles, providing anti-inflammatory and antioxidant properties, while the electrospun layer ensured prolonged antibacterial activity through sustained iodine release. The scaffold's macroporous structure facilitated cell infiltration and proliferation, reducing inflammation and regulating ROS levels. The bilayer system demonstrated significant multifunctional properties, promoting successful healing of chronic wounds in both in-vitro and in-vivo studies.
