14 citations
,
October 2020 in “Natural Products and Bioprospecting” This review discusses current topical treatments, natural products, and complementary therapies for androgenetic alopecia, but it reports no new clinical results.
22 citations
,
March 2020 in “Cosmetics” This review discusses the potential of nanotechnology-based formulations for delivering topical minoxidil to improve hair loss treatment outcomes and reports no new clinical results, urging further research into their benefits and safety considerations.
68 citations
,
January 2020 in “International Journal of Pharmaceutics” Vitamin C-based nanovesicles effectively treat acne.
46 citations
,
September 2018 in “Expert Opinion on Drug Delivery” This study reported that nanostructured lipid carriers with melatonin improved hair density and decreased hair loss in patients with androgenic alopecia, suggesting a promising direction for future treatments.
40 citations
,
July 2018 in “European Journal of Pharmaceutical Sciences” This study found that melatonin-loaded vitamin C-based nanovesicles improved hair thickness, density, and reduced hair loss in patients with androgenic alopecia more effectively than melatonin solution.
58 citations
,
January 2018 in “International Journal of Women's Dermatology” This review discusses the psychological impact of alopecia on women and reports no new clinical findings, highlighting the effect on self-esteem and quality of life.
47 citations
,
April 2017 in “European Journal of Pharmaceutics and Biopharmaceutics” This study found that dutasteride-loaded nanostructured lipid carriers coated with a stearic acid-chitosan oligomer are stable, less cytotoxic, and suitable for topical delivery to promote hair growth.
8 citations
,
March 2017 in “Experimental Dermatology” In this exploratory study, researchers found slightly increased levels of inflammatory markers in scalp skin affected by androgenetic alopecia, suggesting differential gene expression involved in hair cycle and keratin production.
13 citations
,
March 2017 in “Genomics” This study reported that pathways related to apoptosis, cell proliferation, and WNT signaling might be key drivers of hair loss in androgenetic alopecia, guiding potential targets for therapy development.
48 citations
,
January 2017 in “Skin Pharmacology and Physiology” This study found that polymeric nanoparticles may effectively deliver finasteride topically to hair follicles, potentially improving alopecia treatment with fewer side effects than oral forms.
13 citations
,
December 2016 in “Journal of Cosmetic Dermatology” This study found increased oxidative stress in younger male patients with early-onset androgenetic alopecia compared to healthy peers, suggesting a potential role for antioxidants in their treatment.
32 citations
,
April 2016 in “Aaps Pharmscitech” This study found that nanostructured lipid carriers enhanced the skin penetration and retention of minoxidil compared to solid lipid nanoparticles, suggesting they could be a promising method for topical delivery.
151 citations
,
July 2011 in “Archives of Dermatological Research” This review discusses various strategies to enhance drug delivery through the skin barrier, highlighting liposomes as promising carriers for increased dermal concentrations in topical therapies, but reports no new research results.
5 citations
,
February 2009 in “International Journal of Cosmetic Science” In a study using a placebo-controlled design, the researchers found that coenzyme Q10 may enhance gene expression of age-relevant hair keratins in human hair roots, suggesting potential anti-aging benefits for mature hair.
140 citations
,
January 2009 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This review discusses the application of liposomes in dermatology, highlighting their therapeutic value for drug stabilization, skin penetration enhancement, and treatment of hair follicle-associated disorders, but reports no new clinical results.
126 citations
,
January 2009 in “International Journal of Trichology” This review discusses the potential role of oxidative stress in hair graying and age-related alopecia, emphasizing the need for new strategies to counteract these effects, but reports no new results.
29 citations
,
January 2009 in “International Journal of Trichology” This report describes two cases of gynecomastia linked to the use of Finasteride (Propecia®) for treating androgenetic alopecia, highlighting a rare but important side effect.
56 citations
,
January 2007 in “Pharmaceutical Development and Technology” This study found that finasteride-loaded liposomal formulations achieved significantly higher skin permeation and deposition compared to conventional gels and solutions, suggesting potential for effective topical application.
63 citations
,
April 2003 in “Journal of The European Academy of Dermatology and Venereology” This study found that minoxidil topical solution was associated with a dose-related occurrence of hypertrichosis, especially facial hair, in women treated for androgenetic alopecia.
165 citations
,
December 2002 in “Molecular and Cellular Endocrinology” This study found that finasteride improves scalp hair growth in men with male pattern hair loss by reducing scalp dihydrotestosterone levels, but it did not benefit postmenopausal women with female pattern hair loss.
174 citations
,
November 2002 in “Expert Reviews in Molecular Medicine” This review discusses the genetic factors contributing to androgenetic alopecia and highlights the potential for developing more effective therapies based on recent discoveries, but reports no new clinical results.
62 citations
,
May 1997 in “Journal of Pharmaceutical Sciences” This study concluded that sebaceous glands are the main pathway for the antiandrogen RU 58841 to permeate the skin, with liposomes enhancing localization in these glands.
71 citations
,
May 1991 in “Clinical and Experimental Dermatology” Young men with male pattern baldness lose hair density over time without treatment.