The Mitochondrial Blueprint of Skin Aging: From Damage Signals to Dermatologic Interventions

Mitochondria play a crucial role in skin health and aging by regulating energy production and cellular processes. As we age and with UV exposure, mitochondrial dysfunction leads to skin aging signs such as collagen degradation and delayed wound healing. Recent studies suggest that targeting mitochondria with interventions like NAD⁺ precursors, antioxidants, and photobiomodulation can restore mitochondrial function, enhance skin repair, and protect against damage. These findings suggest that mitochondria-targeted therapies could revolutionize anti-aging and wound-care treatments in dermatology.