The Mitochondrial Blueprint of Skin Aging: From Damage Signals to Dermatologic Interventions

The document explores the pivotal role of mitochondria in skin aging, emphasizing how mitochondrial dysfunction leads to issues like collagen degradation, pigmentation changes, and inflammation. It highlights the accumulation of mitochondrial DNA damage and its impact on oxidative stress and skin aging. The review discusses potential therapeutic interventions, such as NAD⁺ boosters, sirtuin activators, and antioxidants, which show promise in preclinical studies for improving mitochondrial health and reversing skin aging. These therapies aim to enhance mitochondrial function, reduce inflammation, and promote skin regeneration. However, the document stresses the need for more robust human trials to validate the long-term efficacy and safety of these interventions and calls for comprehensive approaches that combine these therapies with traditional skin care methods.