The Role of Mitochondria in Skin Aging

April 2023 in “ Journal of Investigative Dermatology ”

S. Yamamura, H. Horiguchi, J. Aoi, Y. Oike, S. Fukushima

mitochondria mitochondrial dysfunction epidermis hair density hair regrowth hair follicle maintenance organ aging

TLDR Mitochondrial dysfunction contributes to skin aging and hair loss.

The study "The role of mitochondria in skin aging" aimed to determine the changes in mitochondria associated with aging in epidermal cells and the effect of mitochondrial dysfunction on aging phenotypes. The researchers compared young wild-type mice (3-month-old) and aged wild-type mice (25-month-old) to examine changes in the epidermis. They found that mitochondrial DNA content was significantly decreased in the epidermis from aged mice compared to young mice. Aged mice also had significantly reduced dorsal hair density and significantly delayed hair regrowth after depilation compared to young mice. Mice with dysfunctional mitochondria exhibited similar age-related phenotypes. These findings suggest that age-related mitochondrial dysfunction in the epidermis affects hair follicle maintenance and regeneration, indicating that mitochondrial dysfunction contributes to organ aging. Maintaining mitochondrial function may prevent age-related organ dysfunction.

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