The Orchestrated Network of Skin Photoaging: From Intercellular Crosstalk to Molecular Signaling
March 2026
in “
BioScience Trends
”
Studysummary This review explores how various skin cell types contribute to photoaging driven by UV radiation, detailing their interactions and molecular mechanisms like oxidative stress and ECM degradation, ultimately offering insights for future anti-photoaging strategies.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This review explores the complex network of cellular and molecular mechanisms driving skin photoaging due to chronic UV radiation, which results in wrinkles, dyspigmentation, and loss of elasticity. It highlights key pathways such as oxidative stress, apoptosis, dysregulated autophagy, inflammatory cascades, and ECM degradation. The review emphasizes the roles and interactions among fibroblasts, keratinocytes, melanocytes, and immune cells, offering an integrated perspective on UV-induced skin aging. This comprehensive understanding of cellular crosstalk and the immune microenvironment provides a foundation for developing advanced anti-photoaging strategies.
