Skin Biology: Understanding Biological Targets for Improving Appearance

    January 2009 in “ Elsevier eBooks ”
    John E. Oblong, Cheri Millikin
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    TLDR The document concludes that a deeper understanding of skin aging and photodamage is needed to create better skin treatments.
    In 2009, the document provided a comprehensive overview of skin biology, detailing the structure and function of the epidermis and dermis, the processes of keratinocyte differentiation, melanogenesis, and the impact of aging and environmental factors like UV damage on skin health. It explained how UV exposure leads to reactive oxygen species (ROS) production, causing fine lines, wrinkles, altered pigmentation, and decreased collagen synthesis, while intrinsic aging results in diminished metabolic and repair capacities. The paper also discussed treatments for photodamage and aging, including hydroxy acids, dermal fillers, Botox, and technologies that stimulate collagen synthesis or provide antioxidants. It highlighted the rise of light-based systems and home-use devices in the aesthetics market, emphasizing the need for a deeper understanding of the mechanisms behind photodamage and aging to develop more effective treatments.
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