Dermatologic Manifestations of Mitochondrial Dysfunction: A Review of the Literature
March 2024
in “
International journal of molecular sciences
”
mitochondrial dysfunction mtDNA deletions mtDNA mutations mtDNA damage skin aging hair loss impaired wound healing systemic lupus erythematosus psoriasis vitiligo atopic dermatitis mitochondrial function mitochondrial DNA deletions mitochondrial DNA mutations mitochondrial DNA damage wound healing lupus eczema
TLDR Mitochondrial dysfunction is linked to various skin conditions and could be a target for treatments.
The review "Dermatologic Manifestations of Mitochondrial Dysfunction: A Review of the Literature" discusses the role of mitochondria in various skin conditions. Mitochondrial DNA (mtDNA) deletions, mutations, and damage are associated with signs of skin aging, hair loss, and impaired wound healing. Several skin conditions, including systemic lupus erythematosus, psoriasis, vitiligo, and atopic dermatitis, are linked with abnormal mitochondrial activity. Mouse model studies have shown a causal relationship between mitochondrial damage and dermatologic outcomes, with some showing reversibility upon restoration of mitochondrial function. The review concludes that mitochondrial function mediates a variety of dermatologic conditions, and mitochondrial components may be a promising target for therapeutic strategies.
