Comparison of Mitochondrial Transplantation Using a Stamp-Type Multineedle Injector and Platelet-Rich Plasma Therapy for Hair Aging in Naturally Aging Mice
October 2020
in “
Biomedicine & Pharmacotherapy
”
mitochondrial transplantation platelet-rich plasma PRP Pep-1-conjugated mitochondria P-Mito anagen follicles dermal collagen subcutaneous fat Klotho gene hair regrowth aging-associated gene markers mitochondrial therapy Pep-1 mitochondria hair follicles skin collagen fat layer Klotho hair growth aging genes
TLDR Mitochondrial therapy and platelet-rich plasma therapy both stimulated hair regrowth in aging mice, with mitochondrial therapy showing similar effectiveness to plasma therapy.
The study investigated the effectiveness of platelet-rich plasma (PRP) therapy and mitochondrial transplantation in treating hair aging in 100-week-old mice. The mice received weekly injections of 200 µg of allogeneic mitochondria or human PRP for a month. Both treatments stimulated hair regrowth, but Pep-1-conjugated mitochondria (P-Mito) maintained hair length until day 28 and yielded more anagen follicles with abundant dermal collagen, similar to the PRP group. P-Mito also increased the thickness of subcutaneous fat compared to the control and PRP groups. The study concluded that P-Mito treatment was as effective as PRP treatment in reducing aging-associated gene markers and increasing antiaging Klotho gene expression, suggesting mitochondrial therapy could be effective in restoring aging-related hair loss.
