20 citations
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December 2017 in “Cardiovascular diabetology” This study found that the DPP-4 inhibitor linagliptin slowed the progression of premature aging characteristics in klotho-/- mice, including improved body weight, cognitive function, and hair retention.
9 citations
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July 2020 in “Biomedicine & Pharmacotherapy” This study found that Pep-1-mediated mitochondrial transplantation was as effective as PRP therapy in restoring hair loss related to aging in mice, with distinct improvements in hair and skin-related measures.
October 2005 in “The Journal of clinical investigation/The journal of clinical investigation” This review discusses various theories and mechanisms of aging, highlighting recent findings on the hormone Klotho, which increased lifespan in mice in laboratory settings, but notes a potential trade-off with human health risks.
7 citations
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March 2022 in “International Journal of Molecular Sciences” This study found that FGF21 suppresses inflammation induced by C. acnes in both human skin cells and mouse models, suggesting potential use in acne treatment.
April 2023 in “Journal of Investigative Dermatology” UVA exposure slows skin wound healing, but α-klotho can reverse this effect.