In The Quest To Stymie Time, Will Laboratory Data Stand Up In Man?
October 2005
in “
The Journal of clinical investigation/The journal of clinical investigation
”
TLDR Genetic manipulations that extend lifespan in mice may not work as effectively in humans.
The document from 18 years ago discusses the complexity of aging and the various theories surrounding it. It highlights the discovery that mutations in certain genes can affect longevity, a realization that has advanced the field of molecular gerontology. The document also mentions two significant findings: mice lacking a tumor suppressor-related gene called p63 aged prematurely, showing signs such as hair loss, spine curvature, and reduced physical fitness; and mice overexpressing a hormone called Klotho lived 19-31% longer than their normal counterparts. However, the effects of these genetic manipulations in lab animals may not be as pronounced in more complex organisms like humans. The document also notes that the mechanism by which Klotho extends lifespan is the same as caloric restriction, which increases insulin resistance, a key symptom of diabetes. Despite potential risks, the document suggests that scientists remain hopeful about the possibility of extending human longevity.
