Suppression of Cutibacterium Acnes-Mediated Inflammatory Reactions by Fibroblast Growth Factor 21 in Skin

    Ying Yu, Yingjie Shen, Siyi Zhang, Nan Wang, Lan Luo, Xinyi Zhu, Xiejun Xu, Weitao Cong, Litai Jin, Zhongxin Zhu
    TLDR FGF21 can help reduce skin inflammation caused by C. acnes.
    The study investigates the role of Fibroblast Growth Factor 21 (FGF21) in suppressing inflammatory reactions induced by Cutibacterium acnes (C. acnes) in skin. Using both mouse models (n = 5-6 mice/group) and cultured keratinocytes, the researchers found that FGF21 significantly reduces the expression of pro-inflammatory cytokines (IL-1β, IL-6, IL-8, and TNF-α) and inhibits the NF-κB/MAPK signaling pathways. FGF21 also decreases TLR2 activity, which is crucial in the inflammatory response to C. acnes. These findings suggest that FGF21 has potential therapeutic value in treating C. acnes-induced skin inflammation.
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