Madarosis From Mitochondriopathy

July 2005 in “ Acta Ophthalmologica Scandinavica ”

Josef Finsterer, Simon Brunner

madarosis mitochondriopathy mitochondrial dysfunction oxidative metabolism hair abnormalities eyelash loss

Studysummary This case report suggests that madarosis, or eyelash loss, may be associated with mitochondriopathy, expanding the known causes of madarosis to include this condition.

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The document discussed a case of madarosis, or eyelash loss, in a 79-year-old woman with mitochondriopathy (MCP), a condition not previously linked to madarosis. The patient had a history of various health issues, including cataracts, carcinomas, osteoporosis, and diabetes, but none were found to be the cause of her madarosis. The study suggested that MCP could be responsible for madarosis, supported by previous reports indicating that MCP can manifest in skin and hair abnormalities. In a study of 140 children with MCP, 10% showed hair or skin issues, and research on mice with mtDNA mutations linked MCP to hair loss and other aging symptoms. The findings proposed that MCP should be considered a potential cause of madarosis, especially when other causes are excluded.

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research An X-Linked Gene Involved in Androgenetic Alopecia: A Lesson to Be Learned from Adrenoleukodystrophy

24 citations , January 2000 in “Dermatology”

This study found that men with adrenomyeloneuropathy often experience diffuse hair loss and severe male-pattern baldness, potentially due to the X-linked ALD mutation's role in androgenetic alopecia's genetic spectrum.