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    Glossary Mitochondrial DNA Damage

    harm to DNA in mitochondria affecting cellular energy production

    Mitochondrial DNA damage refers to harm inflicted on the DNA located within the mitochondria, the energy-producing structures in cells. This damage can result from factors like oxidative stress, environmental toxins, or genetic mutations, and it can impair cellular energy production, potentially leading to various diseases and aging-related conditions.

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    1. Mitochondrial DNA Damage, Oxidative Stress, and Atherosclerosis Circulation · 2013 · 12 citations
    2. Defects in mitochondrial DNA replication and oxidative damage in muscle of mtDNA mutator mice Free radical biology & medicine · 2014 · 53 citations
    3. Dermatologic Manifestations of Mitochondrial Dysfunction: A Review of the Literature International journal of molecular sciences · 2024
    4. Differential effects of melatonin as a broad range UV-damage preventive dermato-endocrine regulator Dermato-endocrinology · 2011 · 31 citations
    5. Photosensitized 2-amino-3-hydroxypyridine-induced mitochondrial apoptosis via Smac/DIABLO in human skin cells Toxicology and applied pharmacology · 2016 · 10 citations
    6. Particulate matter 2.5 damages skin cells by inducing oxidative stress, subcellular organelle dysfunction, and apoptosis Archives of Toxicology · 2018 · 215 citations
    7. Dual deficiency of melatonin and dihydrotestosterone promotes stromal cell damage and mediates prostatitis via the cGAS-STING pathway in sleep-deprived mice Cell communication and signaling · 2024
    8. The legacy of Bruce Ames and mitochondrial DNA mutagenicity: integrating oxidative stress, aging, and modern perspectives Frontiers in Molecular Biosciences · 2025
    9. Profiling the Response of Human Hair Follicles to Ultraviolet Radiation Journal of Investigative Dermatology · 2009 · 53 citations
    10. The crosstalk between PTEN ‐induced kinase 1‐mediated mitophagy and the inflammasome in the pathogenesis of alopecia areata Experimental Dermatology · 2023 · 6 citations
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