Transient Mitochondrial DNA Double Strand Breaks in Mice Cause Accelerated Aging Phenotypes in a ROS-Dependent but p53/p21-Independent Manner

    December 2016 in “ Cell Death & Differentiation ”
    Milena Pinto, Alicia M. Pickrell, Xiao Wang, Sandra R. Bacman, Aixin Yu, Aline Hida, Lloye M. Dillon, Paul D. Morton, Thomas R. Malek, Steve K. Williams, Carlos T. Moraes
    Image of study
    TLDR Damaging mitochondrial DNA in mice speeds up aging due to increased reactive oxygen species, not through the p53/p21 pathway.
    The study from December 2016 found that inducing mitochondrial DNA double strand breaks (mtDNA DSBs) in mice led to accelerated aging phenotypes, especially in tissues with high cell turnover. The aging effects were associated with increased levels of reactive oxygen species (ROS) and were observed in the thymus, skin, bone marrow, and testis, as well as in progenitor cells. Importantly, these effects occurred independently of the p53/p21 pathway, as evidenced by the fact that antioxidant treatments alleviated the aging phenotypes, while the knockout of p21 or p53 genes did not prevent them. This suggests that mtDNA damage contributes to aging through ROS production and impacts progenitor cell pools, challenging the previously understood role of the p53/p21 pathway in aging related to mtDNA damage.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 27 results

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  737 upvotes 2 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

      community Sunlight: Does it Stimulate Hair Growth or Hair Loss?

      in Research/Science  61 upvotes 7 months ago
      The conversation discusses whether sunlight exposure affects hair growth or loss, with mixed anecdotes and theories but no clear consensus. Some suggest moderate sunlight can benefit hair by providing vitamin D, while others doubt its effectiveness compared to treatments like Minoxidil or finasteride.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

    Similar Research

    5 / 1000+ results