The Role of Mitochondria in the Non-Targeted Effect of Ionizing Radiation

    April 2018 in “ Radiotherapy and Oncology ”
    Silvana Miranda, Marcelo Correia, A.G. Dias, Paula Boaventura, Valdemar Máximo
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    TLDR Mitochondria may influence how cells respond to radiation, affecting nearby non-irradiated cells.
    The study investigated the role of mitochondria in the non-targeted effects of ionizing radiation using an osteosarcoma cell line manipulated to have different mitochondrial statuses. Results showed that irradiation increased DNA damage in all cell lines, but apoptosis was not observed. Conditioned media from irradiated cells induced DNA damage in non-irradiated cells, with varying effects depending on the mitochondrial status of the cells. The findings suggested a potential role of mitochondria in radiation-induced bystander effects, which could be significant for modulating responses to radiotherapy.
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