Tissue Regenerative Delays and Synthetic Lethality in Adult Mice After Combined Deletion of ATR and TRP53

    August 2009 in “ Nature Genetics ”
    Yaroslava Ruzankina, David W. Schoppy, Amma Asare, Charles C. Clark, Robert H. Vonderheide, Eric J. Brown
    Image of study
    TLDR Removing both Atr and Trp53 genes in adult mice causes severe tissue damage and death due to DNA damage.
    The study conducted 14 years ago demonstrated that the combined deletion of the Atr and Trp53 genes in adult mice resulted in severe tissue degeneration and defects in hair follicle regeneration, as well as accelerated deterioration of the intestinal epithelium and synthetic lethality. The absence of Trp53 exacerbated the lethal phenotype, with a mortality rate of over 94% within two weeks among Trp53-/-Atrmko mice. The degeneration was due to the accumulation of cells with high levels of DNA damage, which hindered regeneration from undamaged progenitors. The study highlighted the critical role of Trp53 in survival following Atr deletion and suggested that ATR-Chk1 inhibitors might be effective in treating Trp53-deficient cancers.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 1000+ results

      community How Does Exosome Therapy Work for Hair Loss?

      in Research/Science  5 upvotes 1 year ago
      Exosome hair therapy involves injecting stem cell-derived exosomes into the scalp to boost hair follicle regeneration and repair. Exosomes, which are not stem cells but products of them, contain bioactive chemicals and specific growth factors that promote new blood vessel formation, increase cell proliferation, reduce inflammation, and improve tissue repair, all crucial for hair health.

      community Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia.

      in Research/Science  13 upvotes 6 months ago
      A quercetin-encapsulated and polydopamine-integrated nanosystem (PDA@QLipo) shows promise for treating androgenetic alopecia by reshaping the perifollicular microenvironment, outperforming minoxidil in hair regeneration. The nanosystem promotes cell proliferation, hair follicle renewal, and recovery by scavenging reactive oxygen species and enhancing neovascularity.

      community Verteporfin and Microneedling

      in Treatments 5 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

    Similar Research

    5 / 1000+ results