DNA Damage, Checkpoint Responses, and Cell Cycle Control in Aging Stem Cells

January 2012 in “ Else Kröner-Fresenius Symposia ”

Karin N. Kleinhans, Martin D. Burkhalter

hair follicle stem cells DNA damage checkpoint responses cell cycle control Bcl-2 Bmi1 homologous recombination hematopoietic stem cells transcription factor BATF

TLDR Maintaining DNA integrity in stem cells is crucial to prevent aging and cancer.

The document discussed the role of DNA damage, checkpoint responses, and cell cycle control in aging stem cells, emphasizing that DNA damage accumulates in aging stem cells, contributing to aging and potential carcinogenesis. Key findings included that hair follicle stem cells were resistant to irradiation-induced apoptosis due to quicker DNA repair and upregulation of anti-apoptotic factors like Bcl-2. The polycomb repressor group gene Bmi1 aided in DNA double strand break repair by stimulating homologous recombination. The mixed-lineage-leukemia-like (MLL)-4 complex mediated aging mechanisms by increasing myeloid lineage potential and cellular stress levels. DNA damage also induced lymphoid differentiation of hematopoietic stem cells via activation of the transcription factor BATF. The study emphasized the importance of maintaining genomic integrity to prevent premature aging and cancer in stem cells.

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