DNA Damage, Checkpoint Responses, and Cell Cycle Control in Aging Stem Cells

    January 2012 in “ Else Kröner-Fresenius Symposia ”
    Karin N. Kleinhans, Martin D. Burkhalter
    Image of study
    TLDR Maintaining DNA integrity in stem cells is crucial to prevent aging and cancer.
    The document discussed the role of DNA damage, checkpoint responses, and cell cycle control in aging stem cells, emphasizing that DNA damage accumulates in aging stem cells, contributing to aging and potential carcinogenesis. Key findings included that hair follicle stem cells were resistant to irradiation-induced apoptosis due to quicker DNA repair and upregulation of anti-apoptotic factors like Bcl-2. The polycomb repressor group gene Bmi1 aided in DNA double strand break repair by stimulating homologous recombination. The mixed-lineage-leukemia-like (MLL)-4 complex mediated aging mechanisms by increasing myeloid lineage potential and cellular stress levels. DNA damage also induced lymphoid differentiation of hematopoietic stem cells via activation of the transcription factor BATF. The study emphasized the importance of maintaining genomic integrity to prevent premature aging and cancer in stem cells.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 1000+ results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

      in Research/Science  92 upvotes 2 years ago
      The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

      community Wtf have we been doing for the last 30 years

      in Treatment  526 upvotes 4 days ago
      Hair loss treatments like finasteride, minoxidil, and dutasteride work but have side effects. A permanent cure is still not available due to the complexity of hair loss and limited investment.

    Similar Research

    5 / 1000+ results