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    Glossary Mitochondrial DNA Damage

    harm to DNA in mitochondria affecting cellular energy production

    Mitochondrial DNA damage refers to harm inflicted on the DNA located within the mitochondria, the energy-producing structures in cells. This damage can result from factors like oxidative stress, environmental toxins, or genetic mutations, and it can impair cellular energy production, potentially leading to various diseases and aging-related conditions.

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    1. Mitochondrial DNA Damage, Oxidative Stress, and Atherosclerosis Circulation · 2013 · 12 citations
    2. Defects in mitochondrial DNA replication and oxidative damage in muscle of mtDNA mutator mice Free radical biology & medicine · 2014 · 53 citations
    3. Dermatologic Manifestations of Mitochondrial Dysfunction: A Review of the Literature International journal of molecular sciences · 2024
    4. Differential effects of melatonin as a broad range UV-damage preventive dermato-endocrine regulator Dermato-endocrinology · 2011 · 31 citations
    5. Photosensitized 2-amino-3-hydroxypyridine-induced mitochondrial apoptosis via Smac/DIABLO in human skin cells Toxicology and applied pharmacology · 2016 · 10 citations
    6. Particulate matter 2.5 damages skin cells by inducing oxidative stress, subcellular organelle dysfunction, and apoptosis Archives of Toxicology · 2018 · 215 citations
    7. Dual deficiency of melatonin and dihydrotestosterone promotes stromal cell damage and mediates prostatitis via the cGAS-STING pathway in sleep-deprived mice Cell communication and signaling · 2024
    8. The legacy of Bruce Ames and mitochondrial DNA mutagenicity: integrating oxidative stress, aging, and modern perspectives Frontiers in Molecular Biosciences · 2025
    9. Profiling the Response of Human Hair Follicles to Ultraviolet Radiation Journal of Investigative Dermatology · 2009 · 53 citations
    10. The crosstalk between PTEN ‐induced kinase 1‐mediated mitophagy and the inflammasome in the pathogenesis of alopecia areata Experimental Dermatology · 2023 · 6 citations
    11. The Charnoly body as a universal biomarker of cell injury Biomarkers and Genomic Medicine · 2014 · 6 citations
    12. 1330 The possible role of PTEN-induced kinase 1-mediated mitophagy by regulating inflammasome activation in the pathogenesis of alopecia areata 2023
    13. Association of mtDNA M/N haplogroups with systemic lupus erythematosus: a case-control study of Han Chinese women Scientific Reports · 2015 · 11 citations
    14. Protective Role of Melatonin and Its Metabolites in Skin Aging International Journal of Molecular Sciences · 2022 · 32 citations
    15. Risk of Polycystic Ovary Syndrome in Women Exposed to Fine Air Pollutants and Acidic Gases: A Nationwide Cohort Analysis International Journal of Environmental Research and Public Health · 2019 · 20 citations
    16. Repurposing Kir6/SUR2 Channel Activator Minoxidil to Arrests Growth of Gynecologic Cancers Frontiers in pharmacology · 2020 · 16 citations
    17. Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology Communications Medicine · 2024 · 7 citations
    18. Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology 2024
    19. 581 Spontaneous, Intrinsic Aging in Organ-Cultured Human Skin as Novel Ex Vivo Assay to Test Candidate Anti-Aging Actives Journal of Investigative Dermatology · 2022
    20. 丹蒽醌對人類惡性黑色素瘤細胞株(A375.S2)誘發細胞週期停滯及細胞凋亡之影響 中山醫學大學醫學研究所學位論文 · 2008
    21. Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner Cell Death & Differentiation · 2016 · 42 citations
    22. Baricitinib Attenuates IFN-γ and Polyinosinic:polycytidylic Acid‒Induced Mitochondrial Damage and Inflammasome Activation in Human Keratinocytes Journal of Investigative Dermatology · 2022
    23. The Mitochondrial Blueprint of Skin Aging: From Damage Signals to Dermatologic Interventions Aging and Disease · 2026
    24. TLR9 activation in large wound induces tissue repair and hair follicle regeneration via gamma delta T cells bioRxiv (Cold Spring Harbor Laboratory) · 2024
    25. THE HUMAN HAIR FOLLICLE AS SENTINEL FOR DRUGS EVALUATION: DEMONSTRATION OF TETRACYCLINE ADHESION TO HAIR FOLLICLE AS PROPOSED MECHANISM IN DYSFUNCTIONAL HAIR LOSS International journal of research - granthaalayah · 2020 · 4 citations
    26. Beyond Circadian Rhythm: Melatonin as a Bio-Regulatory Molecule in Skin and Hair Aesthetics International Journal of Science and Research (IJSR) · 2026
    27. TLR9 activation in large wound induces tissue repair and hair follicle regeneration via γδT cells Cell Death and Disease · 2024
    28. Stem cell rejuvenation and the role of autophagy in age retardation by caloric restriction: An update Mechanisms of Ageing and Development · 2018 · 19 citations
    29. Cellular senescence and polycystic ovary syndrome: mechanisms and therapeutic strategies from a new perspective Annals of Medicine · 2025 · 2 citations
    30. Anagen Effluvium in Association With Extracorporeal Membrane Oxygenation Pediatric Dermatology · 2017 · 2 citations