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    Glossary Mitochondrial Biogenesis

    process of creating new mitochondria within cells

    Mitochondrial biogenesis is the process by which cells increase their individual mitochondrial mass and copy number to meet increased energy demands. This involves the growth and division of pre-existing mitochondria, regulated by various signaling pathways and transcription factors, such as PGC-1α, which coordinate the expression of nuclear and mitochondrial genes.

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    1. Hypothalamic–Pituitary–Thyroid Axis Hormones Stimulate Mitochondrial Function and Biogenesis in Human Hair Follicles Journal of Investigative Dermatology · 2013 · 95 citations
    2. LB1017 A novel link between human hair follicle neuroimmunology and mitochondrial biology: Substance P increases intrafollicular oxidative stress and mitochondrial biogenesis Journal of Investigative Dermatology · 2022
    3. Cedrol ameliorates inflammatory bowel disease via mitochondrial biogenesis, gut microbiota restoration, and intestinal barrier repair Frontiers in Pharmacology · 2026
    4. Regulation of Mitochondrial Oxidative Metabolism by Tumor Suppressor FLCN Journal of the National Cancer Institute · 2012 · 81 citations
    5. Defects in mitochondrial DNA replication and oxidative damage in muscle of mtDNA mutator mice Free radical biology & medicine · 2014 · 53 citations
    6. A NIR-responsive PDA@RES core-shell nanoplatform accelerates chronic wound healing by remodeling mitochondrial homeostasis and reversing cellular senescence Nano Research · 2026
    7. Advances in mitochondria-centered mechanism behind the roles of androgens and androgen receptor in the regulation of glucose and lipid metabolism Frontiers in endocrinology · 2023
    8. 1433 Epithelially derived, mitochondrial MPZL3 negatively regulates murine and human hair follicle cycling Journal of Investigative Dermatology · 2023
    9. Sinapic Acid Promotes Browning of 3T3‐L1 Adipocytes via p38 MAPK/CREB Pathway BioMed Research International · 2020 · 29 citations
    10. Leptin and the skin: a new frontier Experimental Dermatology · 2009 · 108 citations
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