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    Glossary Mitochondrial Biogenesis

    process of creating new mitochondria within cells

    Mitochondrial biogenesis is the process by which cells increase their individual mitochondrial mass and copy number to meet increased energy demands. This involves the growth and division of pre-existing mitochondria, regulated by various signaling pathways and transcription factors, such as PGC-1α, which coordinate the expression of nuclear and mitochondrial genes.

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    1. Hypothalamic–Pituitary–Thyroid Axis Hormones Stimulate Mitochondrial Function and Biogenesis in Human Hair Follicles Journal of Investigative Dermatology · 2013 · 95 citations
    2. LB1017 A novel link between human hair follicle neuroimmunology and mitochondrial biology: Substance P increases intrafollicular oxidative stress and mitochondrial biogenesis Journal of Investigative Dermatology · 2022
    3. Cedrol ameliorates inflammatory bowel disease via mitochondrial biogenesis, gut microbiota restoration, and intestinal barrier repair Frontiers in Pharmacology · 2026
    4. Regulation of Mitochondrial Oxidative Metabolism by Tumor Suppressor FLCN Journal of the National Cancer Institute · 2012 · 81 citations
    5. Defects in mitochondrial DNA replication and oxidative damage in muscle of mtDNA mutator mice Free radical biology & medicine · 2014 · 53 citations
    6. A NIR-responsive PDA@RES core-shell nanoplatform accelerates chronic wound healing by remodeling mitochondrial homeostasis and reversing cellular senescence Nano Research · 2026
    7. Advances in mitochondria-centered mechanism behind the roles of androgens and androgen receptor in the regulation of glucose and lipid metabolism Frontiers in endocrinology · 2023
    8. 1433 Epithelially derived, mitochondrial MPZL3 negatively regulates murine and human hair follicle cycling Journal of Investigative Dermatology · 2023
    9. Sinapic Acid Promotes Browning of 3T3‐L1 Adipocytes via p38 MAPK/CREB Pathway BioMed Research International · 2020 · 29 citations
    10. Leptin and the skin: a new frontier Experimental Dermatology · 2009 · 108 citations
    11. The mechanisms and functions of interorganelle interactions Molecular biology of the cell · 2017 · 5 citations
    12. The Physiological Impact of Melatonin, Its Effect on the Course of Diseases and Their Therapy and the Effect of Magnetic Fields on Melatonin Secretion—Potential Common Pathways of Influence Biomolecules · 2024 · 3 citations
    13. Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner Cell Death & Differentiation · 2016 · 42 citations
    14. Comparison of mitochondrial transplantation by using a stamp-type multineedle injector and platelet-rich plasma therapy for hair aging in naturally aging mice Biomedicine & Pharmacotherapy · 2020 · 9 citations
    15. MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial and ciliary functions by controlling gene promoters Nature communications · 2023 · 1 citations
    16. Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial–Mesenchymal Interactions Journal of Investigative Dermatology · 2015 · 56 citations
    17. A novel and safe small molecule enhances hair follicle regeneration by facilitating metabolic reprogramming Experimental and Molecular Medicine · 2018 · 19 citations
    18. Secreted Frizzled‐Related Protein 2 ( SFRP2 ) Induces Follistatin‐Like 1 ( FSTL1 ) to Regulate Dihydrotestosterone ( DHT )‐Induced Dermal Papilla Cell Mitochondrial Dysfunction and Senescence Aging Cell · 2026
    19. Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development Science Signaling · 2013 · 277 citations
    20. Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Shifting Macrophage-Osteoclast Polarization Cell Metabolism · 2014 · 222 citations
    21. Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis Acta neuropathologica communications · 2019 · 29 citations
    22. Quercitrin Stimulates Hair Growth with Enhanced Expression of Growth Factors via Activation of MAPK/CREB Signaling Pathway Molecules · 2020 · 25 citations
    23. Stem cell rejuvenation and the role of autophagy in age retardation by caloric restriction: An update Mechanisms of Ageing and Development · 2018 · 19 citations
    24. Peroxisome Proliferator–Activated Receptor-γ−Mediated Signaling Regulates Mitochondrial Energy Metabolism in Human Hair Follicle Epithelium Journal of Investigative Dermatology · 2018 · 17 citations
    25. Mitochondrial DNA Damage, Oxidative Stress, and Atherosclerosis Circulation · 2013 · 12 citations
    26. Activation of mitochondrial aldehyde dehydrogenase 2 promotes hair growth in human hair follicles Journal of Advanced Research · 2023 · 11 citations
    27. Peroxisome proliferator-activated receptors-mediated diabetic wound healing regulates endothelial cells’ mitochondrial function via sonic hedgehog signaling Burns & Trauma · 2025 · 5 citations
    28. Unveiling Therapeutic Potential of Yoga Mitigating Oxidative Stress and Mitochondrial Dysfunction in PCOS: A Randomized Controlled Trial International Journal of Yoga · 2025 · 4 citations
    29. Observations that suggest a contribution of altered dermal papilla mitochondrial function to androgenetic alopecia Experimental Dermatology · 2022 · 4 citations
    30. Author response: Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression 2017 · 1 citations