Exploring the Role of Tripeptides in Wound Healing and Skin Regeneration: A Comprehensive Review
October 2025
in “
International Journal of Medical Sciences
”
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Studysummary This review reported that tripeptides, such as GHK and KdPT, show promise in enhancing wound healing through multiple mechanisms, including promoting cell migration, collagen deposition, and angiogenesis, while offering antimicrobial and anti-inflammatory benefits for both acute and chronic wounds.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This comprehensive review highlights the potential of tripeptides in wound healing and skin regeneration, emphasizing their ability to accelerate tissue repair through mechanisms such as cell migration, proliferation, differentiation, and ECM remodeling. Tripeptides like GHK, KdPT, and KPV exhibit antimicrobial and anti-inflammatory properties, enhance fibroblast migration, collagen deposition, and angiogenesis, and combat infections like MRSA. The review also explores the use of tripeptides in nanoparticle conjugates, hydrogels, and clinical derivatives, and discusses their applications beyond wound repair, including cancer and cosmetics. Future research should focus on enhancing the stability, bioavailability, and delivery systems of tripeptides to maximize their clinical potential in regenerative medicine.
