Prevention of Chemotherapy Drug-Mediated Human Hair Follicle Damage: Combined Use of Cooling with Antioxidant Suppresses Oxidative Stress and Prevents Matrix Keratinocyte Cytotoxicity

    July 2025 in “ Frontiers in Pharmacology
    Khalidah Ibraheem, Adrian L. Smith, Andrew Collett, Nikolaos T. Georgopoulos
    The study demonstrates that cooling, when combined with antioxidants, effectively reduces chemotherapy-induced damage to human hair follicles by preventing cell apoptosis and maintaining hair follicle viability and functionality. This approach compensates for insufficient protection under less-than-ideal cooling conditions and shows promise for enhancing the effectiveness of scalp cooling in preventing chemotherapy-induced alopecia (CIA), thereby potentially improving the quality of life for cancer patients undergoing chemotherapy.
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