Results of Scalp Cooling During Anthracycline-Containing Chemotherapy Depend on Scalp Skin Temperature

    December 2016 in “ Breast
    M.M.C. Komen, Carolien H. Smorenburg, J.W.R. Nortier, Tjeerd van der Ploeg, Corina van den Hurk, J.J.M. van der Hoeven
    TLDR Cooler scalp temperatures during chemotherapy may prevent hair loss.
    This study explored the relationship between scalp skin temperature and the effectiveness of scalp cooling in preventing chemotherapy-induced alopecia (CIA) in 62 breast cancer patients undergoing anthracycline-containing chemotherapy. The results indicated that the efficacy of scalp cooling was temperature-dependent, with the best outcomes observed when the scalp temperature decreased below 18°C. Specifically, 21% of patients did not require a wig or head covering, and these patients had a significantly lower mean scalp skin temperature (18°C) compared to those who experienced alopecia (20°C). The study concluded that achieving a scalp skin temperature of at least 18°C is crucial for the success of scalp cooling in preventing CIA.
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