Melatonin Protects K15+ Human Hair Follicle Stem Cells and Hair Matrix Keratinocytes Against Paclitaxel-Induced Damage Ex Vivo

September 2023 in “ Journal of Investigative Dermatology ”

Tara Samra, Jérémy Chéret, Jennifer Gherardini, Samantha Verling, Ramtin Kassir, Ralf Paus

melatonin K15+ human hair follicle stem cells hair matrix keratinocytes paclitaxel chemotherapy-induced alopecia docetaxel antioxidant properties chemotherapy-induced hair loss

TLDR Melatonin may protect hair follicle cells from damage caused by a chemotherapy drug.

The document discusses a study investigating the protective effects of melatonin on K15+ human hair follicle stem cells and hair matrix keratinocytes against damage caused by the chemotherapy drug paclitaxel. The research, conducted ex vivo, found that melatonin significantly reduced the cytotoxic effects of paclitaxel on these cells. This suggests that melatonin, known for its antioxidant properties, could potentially be used to prevent chemotherapy-induced alopecia, a side effect experienced by nearly 100% of patients receiving drugs like paclitaxel and docetaxel. However, the document does not provide specific details about the study, such as the number of participants or the exact methods used.

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