Melatonin Protects K15+ Human Hair Follicle Stem Cells and Hair Matrix Keratinocytes Against Paclitaxel-Induced Damage Ex Vivo

    September 2023 in “ Journal of Investigative Dermatology
    Tara Samra, Jérémy Chéret, Jennifer Gherardini, Samantha Verling, Ramtin Kassir, Ralf Paus
    Image of study
    TLDR Melatonin may protect hair follicle cells from damage caused by a chemotherapy drug.
    The document discusses a study investigating the protective effects of melatonin on K15+ human hair follicle stem cells and hair matrix keratinocytes against damage caused by the chemotherapy drug paclitaxel. The research, conducted ex vivo, found that melatonin significantly reduced the cytotoxic effects of paclitaxel on these cells. This suggests that melatonin, known for its antioxidant properties, could potentially be used to prevent chemotherapy-induced alopecia, a side effect experienced by nearly 100% of patients receiving drugs like paclitaxel and docetaxel. However, the document does not provide specific details about the study, such as the number of participants or the exact methods used.
    Discuss this study in the Community →

    Research cited in this study

    30 / 30 results

    Related Community Posts Join

    6 / 258 results

      community Is anyone using melatonin for hair loss?

      in Research/Science  9 upvotes 6 months ago
      Melatonin is being discussed as a potential treatment for hair loss, with questions about its effectiveness and whether it should be used topically or orally. No specific conclusions or personal experiences were shared.

      community Melatonin options for Europe??? *Retrograde Alopecia*

      in Product  3 upvotes 7 months ago
      A user is considering using melatonin for hair recovery on the side and neck area but is unsure about the best options in Europe and whether a dietary supplement form can be applied to the scalp. They found a product but are hesitant and seeking opinions on its use for alopecia.

      community Optimal dose for topical Melatonin

      in Treatment  6 upvotes 1 year ago
      The conversation is about finding the optimal concentration of topical melatonin for hair loss treatment. The user is considering making their own solution and is unsure whether a higher concentration is more effective for deactivating prolactin receptors.

      community Compounding Topical Melatonin at Home

      in Treatment  8 upvotes 3 years ago
      Melatonin at a 0.0033% concentration shows results for hair loss when used topically. A user is discussing how to replicate this by adding 2mg of Melatonin to 60ml of Minoxidil solution.

      community Melatonin a possible tool to help fight AGA hair loss.

      in Research/Science  50 upvotes 3 years ago
      Topical melatonin may help reduce hair loss and increase hair thickness in people with androgenetic alopecia (AGA), with some studies showing positive results. It can be mixed with minoxidil for application, and its effectiveness might be enhanced when used with micro-needling, but results may vary among individuals.

    Similar Research

    5 / 1000+ results