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    Melatonin Protects K15+ Human Hair Follicle Stem Cells and Hair Matrix Keratinocytes Against Paclitaxel-Induced Damage Ex Vivo

    September 2023 in “ Journal of Investigative Dermatology
    Tara Samra, Jérémy Chéret, Jennifer Gherardini … Ralf Paus
    Studysummary This article discusses the mechanisms behind chemotherapy-induced alopecia and the potential for permanent hair loss due to irreversible damage to hair follicle stem cells, but it reports no new clinical findings.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 36

    1. Redefining The Crown: Approaching Chemotherapy-Induced Alopecia Among Black Patients With Breast Cancer Cancer · 2023
    2. Low-Intensity Ultrasound as a Potential Intervention Strategy to Protect Human Scalp Hair Follicles from Taxane-Induced Toxicity Journal of Investigative Dermatology · 2023
    3. Prevention and Treatment of Chemotherapy-Induced Alopecia: What Is Available and What Is Coming? Current Oncology · 2023
    4. Drugs Targeting Epithelial–Mesenchymal Transition Molecules for Treatment of Lichen Planopilaris Clinical and experimental dermatology · 2022
    5. Revisiting the Role of Melatonin in Human Melanocyte Physiology: A Skin Context Perspective Journal of pineal research · 2022
    6. Protective Role of Melatonin and Its Metabolites in Skin Aging International Journal of Molecular Sciences · 2022
    7. Improving Preparation for Scalp Cooling: Learning from Women Undergoing Chemotherapy for Early-Stage Breast Cancer—The COOL Study Journal of Clinical Nursing · 2021
    8. Peroxisome Proliferator-Activated Receptor-γ Signalling Protects Hair Follicle Stem Cells from Chemotherapy-Induced Apoptosis and Epithelial-Mesenchymal Transition British journal of dermatology/British journal of dermatology, Supplement · 2021
    9. Resident Human Dermal Gamma Delta T-Cells Operate as Stress Sentinels: Lessons from the Hair Follicle Journal of Autoimmunity · 2021
    10. Sensory Reinnervation of Human Skin by Human Neural Stem Cell-Derived Peripheral Neurons Ex Vivo ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2021
    11. The Global Regulatory Logic Of Organ Regeneration: Circuitry Lessons From Skin And Its Appendages Biological reviews/Biological reviews of the Cambridge Philosophical Society · 2021
    12. Human Epithelial Stem Cell Survival Within Their Niche Requires Tonic Cannabinoid Receptor 1 Signaling—Lessons From the Hair Follicle Experimental Dermatology · 2021
    13. Identifying the Supportive Care Needs of Men and Women Affected by Chemotherapy-Induced Alopecia: A Systematic Review Journal of cancer survivorship · 2020
    14. Protective Effects of Melatonin on the Skin: Future Perspectives International Journal of Molecular Sciences · 2019
    15. CDK4/6 Inhibition Mitigates Stem Cell Damage in a Novel Model for Taxane-Induced Alopecia EMBO Molecular Medicine · 2019
    16. Assessment of Quality of Life and Treatment Outcomes of Patients With Persistent Postchemotherapy Alopecia JAMA Dermatology · 2019
    17. Culture of the Human Pilosebaceous Unit, Hair Follicle, and Sebaceous Gland Experimental Dermatology · 2018
    18. Hair Disorders in Patients with Cancer Journal of The American Academy of Dermatology · 2018
    19. Melatonin: A Cutaneous Perspective on Its Production, Metabolism, and Functions Journal of Investigative Dermatology · 2018
    20. Divergent Proliferation Patterns of Distinct Human Hair Follicle Epithelial Progenitor Niches In Situ and Their Differential Responsiveness to Prostaglandin D2 Scientific Reports · 2017
    21. Epithelial-To-Mesenchymal Stem Cell Transition In A Human Organ: Lessons From Lichen Planopilaris Journal of Investigative Dermatology · 2017
    22. Oxidative Damage Control in a Human Mini-Organ: Nrf2 Activation Protects Against Oxidative Stress-Induced Hair Growth Inhibition Journal of Investigative Dermatology · 2016
    23. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    24. Human Hair Follicle Organ Culture: Theory, Application, and Perspectives Experimental Dermatology · 2015
    25. Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges BioEssays · 2014
    26. Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche The Journal of Pathology · 2013
    27. Pathobiology of Chemotherapy-Induced Hair Loss The Lancet Oncology · 2013
    28. Topical Melatonin for Treatment of Androgenetic Alopecia International Journal of Trichology · 2012
    29. Methods in Hair Research: How to Objectively Distinguish Between Anagen and Catagen in Human Hair Follicle Organ Culture Experimental Dermatology · 2009
    30. Dissecting the Impact of Chemotherapy on the Human Hair Follicle ˜The œAmerican journal of pathology · 2007
    31. Gene Expression Profiling Gets to the Root of Human Hair Follicle Stem Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    32. The Role of Melatonin in Neuroectodermal-Mesodermal Interactions: The Hair Follicle Synthesizes Melatonin and Expresses Functional Melatonin Receptors ˜The œFASEB journal · 2005
    33. A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice Journal of Investigative Dermatology · 2005
    34. Melatonin Increases Anagen Hair Rate in Women With Androgenetic Alopecia or Diffuse Alopecia: Results of a Pilot Randomized Controlled Trial British Journal of Dermatology · 2004
    35. Human Hair Growth In Vitro: A Model for the Study of Hair Follicle Biology Journal of Dermatological Science · 1994
    36. Murine Skin as a Target for Melatonin Bioregulation Experimental dermatology · 1994