Protective Effects of Melatonin on the Skin: Future Perspectives

    October 2019 in “ International Journal of Molecular Sciences ”
    Iryna Rusanova, Laura Martínez-Ruiz, Javier Florido … Germaine Escames
    Studysummary This article reviews various studies and suggests that melatonin, produced both naturally in the skin and applied topically, may offer significant protection against environmental damage, making it a promising candidate for skincare therapies.
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    Research cited in this study 16

    1. Biochemical and Histopathological Evaluation of the Radioprotective Effects of Melatonin Against Gamma Ray-Induced Skin Damage Current radiopharmaceuticals · 2018
    2. Clinical Cosmeceutical Repurposing of Melatonin in Androgenic Alopecia Using Nanostructured Lipid Carriers Prepared with Antioxidant Oils Expert Opinion on Drug Delivery · 2018
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    4. Roles of the Hedgehog Signaling Pathway in Epidermal and Hair Follicle Development, Homeostasis, and Cancer Journal of developmental biology · 2017
    5. Stem Cell and Extracellular Matrix-Related Molecules Increase Following Melatonin Treatment in the Skin of Postmenopausal Rats Cell biology international · 2014
    6. Melatonin Membrane Receptors in Peripheral Tissues: Distribution and Functions Molecular and Cellular Endocrinology · 2012
    7. Topical Melatonin for Treatment of Androgenetic Alopecia International Journal of Trichology · 2012
    8. Human Skin Stem Cells and the Aging Process Experimental gerontology · 2008
    9. Melatonin as a Major Skin Protectant: From Free Radical Scavenging to DNA Damage Repair Experimental dermatology · 2008
    10. Melatonin in the Skin: Synthesis, Metabolism, and Functions Trends in Endocrinology and Metabolism · 2008
    11. Melatonin and the Hair Follicle Journal of pineal research · 2007
    12. The Role of Melatonin in Neuroectodermal-Mesodermal Interactions: The Hair Follicle Synthesizes Melatonin and Expresses Functional Melatonin Receptors ˜The œFASEB journal · 2005
    13. Ultrastructural Evaluation of the Radioprotective Effects of Melatonin Against X-Ray-Induced Skin Damage in Albino Rats International journal of experimental pathology · 2005
    14. On the Role of Melatonin in Skin Physiology and Pathology Endocrine journal · 2005
    15. Characterization of the Serotoninergic System in the C57BL/6 Mouse Skin European journal of biochemistry · 2003
    16. Serotoninergic And Melatoninergic Systems Are Fully Expressed In Human Skin ˜The œFASEB journal · 2002