Biochemical and Histopathological Evaluation of the Radioprotective Effects of Melatonin Against Gamma Ray-Induced Skin Damage

Five years ago, a study was conducted on 60 male Wistar rats to assess the radioprotective effects of melatonin against gamma ray-induced skin damage. The rats were divided into four groups: control, melatonin, radiation, and melatonin + radiation. The results indicated that melatonin significantly reduced malondialdehyde (MDA) levels and increased catalase (CAT) and superoxide dismutase (SOD) activities, suggesting reduced oxidative stress. Histopathological examination showed significant differences in skin damage between the radiation group and the other groups, with the melatonin + radiation group showing less damage. The study concluded that melatonin could be used effectively for the prevention and treatment of radiation-induced skin injury, recommending its use in optimal and safe doses over a long period for effective radioprotection and skin damage amelioration.