Peroxisome Proliferator-Activated Receptor-γ Signalling Protects Hair Follicle Stem Cells from Chemotherapy-Induced Apoptosis and Epithelial-Mesenchymal Transition

    Ilaria Piccini, Lars Brunken, Jérémy Chéret, Sushmita Ghatak, Yuval Ramot, Majid Alam, Talveen S. Purba, Jonathan A. Hardman, Hanieh Erdmann, Francisco Jiménez, Ralf Paus, Marta Bertolini
    TLDR Activating PPAR-γ signalling can protect hair follicle stem cells from damage caused by chemotherapy.
    The study investigated the role of epithelial hair follicle stem cells (eHFSCs) in permanent chemotherapy-induced alopecia (pCIA) and tested a potential preventive treatment. Human scalp hair follicles (HFs) were exposed to 4-hydroperoxycyclophosphamide (4-HC), a metabolite of the chemotherapy drug cyclophosphamide, which induced apoptosis, DNA damage, and pathological epithelial-mesenchymal transition (EMT) in eHFSCs. Pretreatment with the PPAR-γ modulator N-acetyl-GED-0507-34-Levo (NAGED) protected against these effects, preserving the eHFSCs. The findings suggest that PPAR-γ signalling could be a novel intervention strategy to prevent pCIA by targeting apoptosis, DNA damage, and EMT in eHFSCs.
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      Diffuse hair loss and scalp biopsies

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      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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