Peroxisome Proliferator-Activated Receptor-γ Signalling Protects Hair Follicle Stem Cells from Chemotherapy-Induced Apoptosis and Epithelial-Mesenchymal Transition

    September 2021 in “ British journal of dermatology/British journal of dermatology, Supplement ”
    Ilaria Piccini, Lars Brunken, Jérémy Chéret … Marta Bertolini
    Studysummary This study suggests that pretreatment with a PPAR-γ modulator may prevent damage to hair follicle stem cells caused by a chemotherapy metabolite, potentially offering a strategy to mitigate permanent chemotherapy-induced alopecia.
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    Research cited in this study 34

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    5. Assessment of Quality of Life and Treatment Outcomes of Patients With Persistent Postchemotherapy Alopecia JAMA Dermatology · 2019
    6. Transepidermal UV Radiation of Scalp Skin Ex Vivo Induces Hair Follicle Damage That Is Alleviated by Topical Treatment with Caffeine International Journal of Cosmetic Science · 2019
    7. Permanent Chemotherapy-Induced Alopecia in Patients with Breast Cancer: A 3-Year Prospective Cohort Study ˜The œoncologist · 2018
    8. Persistent Major Alopecia Following Adjuvant Docetaxel for Breast Cancer: Incidence, Characteristics, and Prevention with Scalp Cooling Breast Cancer Research and Treatment · 2018
    9. Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases Trends in Molecular Medicine · 2018
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    25. Folliculitis Decalvans Associated with Erlotinib Clinical and Experimental Dermatology · 2010
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