Cutaneous Reactions to Chemotherapeutic Agents

May 2001 in “ The American journal of the medical sciences ”

Robert A. Koppel, Erin Boh

TLDR Chemotherapy can cause various skin problems, and recognizing them helps improve patient care.

The document reviewed various cutaneous reactions to chemotherapeutic agents, highlighting the complexity of evaluating skin eruptions in immunosuppressed oncology patients. Common reactions included mucositis, alopecia, hypersensitivity reactions, hyperpigmentation, onychodystrophy, acral erythema, and radiation reactions. Specific agents like methotrexate, suramin, doxorubicin, 5-fluorouracil, docetaxel, and interferon were noted for causing severe skin reactions. The document emphasized the importance of recognizing these patterns to avoid unnecessary discontinuation of effective treatments and improve patient care.

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Research cited in this study

4 / 4 results

research A Randomized Trial of Minoxidil in Chemotherapy-Induced Alopecia

127 citations , July 1996 in “Journal of The American Academy of Dermatology”

Minoxidil shortens baldness from chemotherapy by 50.2 days without significant side effects.

research Cutaneous Reactions to Recombinant Cytokine Therapy

105 citations , September 1995 in “Journal of The American Academy of Dermatology”

Recombinant cytokine therapy can cause skin reactions ranging from mild to severe.

research Chemotherapy-Induced Alopecia

52 citations , May 1993 in “Southern Medical Journal”

Imuvert can prevent some chemotherapy-induced hair loss.

research Cutaneous Complications of Chemotherapeutic Agents

172 citations , November 1983 in “Journal of The American Academy of Dermatology”

Chemotherapy can cause skin problems like hair loss, mouth sores, and skin darkening, and recognizing these can affect treatment decisions.

Semantic ratio: 80%