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GlossaryMethotrexate (MTX)

inhibits cell growth by blocking folic acid metabolism

Methotrexate (MTX) is a medication commonly used to treat certain types of cancer, autoimmune diseases like rheumatoid arthritis, and severe psoriasis. It works by inhibiting the metabolism of folic acid, which is necessary for the rapid growth of cells, thereby slowing down the proliferation of cancer cells and modulating the immune system.

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research Is Methotrexate an Effective and Safe Treatment for Maintaining Hair Regrowth in People with Alopecia Totalis? A Critically Appraised Topic

12 citations , May 2018 in “British journal of dermatology/British journal of dermatology, Supplement”

Methotrexate's effectiveness for maintaining hair regrowth in alopecia totalis is unclear due to limited and biased data.

research Non-Biologic Immunosuppressive Drugs for Inflammatory and Autoimmune Skin Diseases

January 2024 in “Journal der Deutschen Dermatologischen Gesellschaft”

Non-biologic immunosuppressive drugs are crucial for treating autoimmune and chronic inflammatory skin diseases.

research Intralesional Methotrexate Versus Triamcinolone Acetonide for Localized Alopecia Areata Treatment

July 2025 in “The Egyptian Journal of Hospital Medicine”

Both treatments improved alopecia areata, but methotrexate caused more skin darkening, while triamcinolone caused skin lightening and thinning.

research Low-Dose Oral Minoxidil in Lichen Planopilaris: Efficacy and Safety

January 2025 in “Dermatologic Therapy”

Low-dose oral minoxidil may help with symptoms and hair regrowth in lichen planopilaris without serious side effects.

research Incidence of Serious Infectious Events with Methotrexate Treatment: Meta-Analysis of Randomized Controlled Trials

February 2010 in “Journal of The American Academy of Dermatology”

Methotrexate treatment for rheumatoid arthritis has a serious infection rate of about two per 100 patient-years.

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community 6months update minox 5% twice daily , dermaroller 1.5mm , ketoconazole shampoo 2% 3,4 times per week and a good buzz cut LOL

in Progress Pictures 98 upvotes 3 years ago

A user's progress with hair loss treatments including minoxidil 5% twice daily, dermaroller 1.5mm, ketoconazole shampoo 2%, and a buzz cut; other users were surprised by the results as no finasteride was included in the treatment plan.

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

in Finasteride/Dutasteride 25 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.