Cooling-Mediated Protection from Chemotherapy Drug-Induced Cytotoxicity in Human Keratinocytes by Inhibition of Cellular Drug Uptake

    October 2020 in “ PLoS ONE ”
    Christopher Dunnill, Khalidah Ibraheem, Michael Peake … Nikolaos T. Georgopoulos
    Studysummary This study found that scalp cooling markedly reduces cellular uptake of anthracycline drugs in human keratinocytes, partially explaining its protective effect against chemotherapy-induced cytotoxicity.
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    Research cited in this study 9

    1. CDK4/6 Inhibition Mitigates Stem Cell Damage in a Novel Model for Taxane-Induced Alopecia EMBO Molecular Medicine · 2019
    2. A Clinical and Biological Guide for Understanding Chemotherapy-Induced Alopecia and Its Prevention Oncologist · 2017
    3. Oxidative Damage Control in a Human Mini-Organ: Nrf2 Activation Protects Against Oxidative Stress-Induced Hair Growth Inhibition Journal of Investigative Dermatology · 2016
    4. Testing Chemotherapeutic Agents in the Feather Follicle Identifies a Selective Blockade of Cell Proliferation and a Key Role for Sonic Hedgehog Signaling in Chemotherapy-Induced Tissue Damage Journal of Investigative Dermatology · 2014
    5. Efficacy of Interventions for Prevention of Chemotherapy-Induced Alopecia: A Systematic Review and Meta-Analysis International journal of cancer · 2014
    6. Pathobiology of Chemotherapy-Induced Hair Loss The Lancet Oncology · 2013
    7. Presentation, Impact and Prevention of Chemotherapy-Induced Hair Loss: Scalp Cooling Potentials and Limitations Expert review of dermatology · 2011
    8. Dissecting the Impact of Chemotherapy on the Human Hair Follicle ˜The œAmerican journal of pathology · 2007
    9. A Hot New Twist to Hair Biology: The Role of TRPV1 in Human Hair Growth Control ˜The œAmerican journal of pathology (Print) · 2005