Plakophilin 1 Suppresses Keratinocyte Innate Immune Responses Through DExD/H Helicases

    August 2026
    Rene Keil, Danny Misiak, Stefan Hüttelmaier … Mechthild Hatzfeld
    Studysummary This study found that Plakophilin 1 regulates innate immune responses in keratinocytes by controlling RNA helicase activity, balancing inflammation during epidermal immune challenges.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 3

    1. The Immune Functions of Keratinocytes in Skin Wound Healing International Journal of Molecular Sciences · 2020
    2. Epidermal Polarity Genes in Health and Disease Cold Spring Harbor Perspectives in Medicine · 2014
    3. Mechanisms Regulating Skin Immunity and Inflammation Nature Reviews Immunology · 2014