H3K9me3 Methyltransferase SETDB1 Controls Retrotransposon Silencing, DNA Methylation, Constitutive Heterochromatin Maintenance and 3D-Chromatin Structure in Epidermal Keratinocytes
H3K9me3 SETDB1 epidermal keratinocytes heterochromatin transposable elements endogenous retroviruses DNA hypomethylation chromatin states double-stranded RNAs interferon-mediated immune response skin inflammation hair loss differentially methylated regions DNA accessibility RNA sequencing antiviral response pathways reverse transcriptase inhibitors T cell infiltration epidermal homeostasis inflammatory skin conditions ERVs DMRs RT inhibitors
Studysummary In this study, researchers found that the loss of SETDB1 in epidermal keratinocytes led to altered chromatin states, increased ERV expression, and activation of immune responses, while inhibiting these effects with certain antiviral drugs reduced skin inflammation and hair loss in a mouse model.
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