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research Research Snippets: Dermatological Genetics and Conditions

July 2005 in “British Journal of Dermatology”

New gene mutations linked to skin conditions were found, bacteria and chemicals may worsen acne, a dog mutation could exist in humans, virus-like elements might be involved in psoriasis, and a vitamin D3 treatment doesn't prevent chemotherapy-related hair loss.

H3K9me3 Methyltransferase SETDB1 Controls Retrotransposon Silencing, DNA Methylation, Constitutive Heterochromatin Maintenance and 3D-Chromatin Structure in Epidermal Keratinocytes

research H3K9me3 Methyltransferase SETDB1 Controls Retrotransposon Silencing, DNA Methylation, Constitutive Heterochromatin Maintenance and 3D-Chromatin Structure in Epidermal Keratinocytes

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

SETDB1 is essential for controlling DNA methylation, silencing retrotransposons, and maintaining skin cell health, with its absence leading to skin inflammation and hair loss.

research Alopecia in Harlequin Mutant Mice Is Associated with Reduced AIF Protein Levels and Expression of Retroviral Elements

4 citations, December 2020 in “Mammalian genome”

Harlequin mutant mice have hair loss due to low AIF protein levels and retroviral element activity.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations, February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

research Mutant Laboratory Mice With Abnormalities in Hair Follicle Morphogenesis, Cycling, and Structure: Annotated Tables

86 citations, December 2001 in “Experimental dermatology”

Mutant mice help researchers understand hair growth and related genetic factors.

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community GFM Gel - High concentration topical gel of Mimicking Growth Factors (GFm), a complex of polypeptides that mimic the action of endogenous growth factors and promote physiological hair regrowth. Helps strengthen the hair bulb and redensify the hair.

in Product 6 upvotes 2 months ago

The conversation discusses using GFM Gel, a topical gel with polypeptides that mimic growth factors to promote hair regrowth and strengthen hair. It also mentions treatments like Minoxidil, finasteride, and RU58841 for hair loss.

community Using Fin and Alfatradiol in conjunction?

in Finasteride/Dutasteride 5 upvotes 3 years ago

User considers adding Alfatradiol to their topical finasteride treatment for hair loss. Others discuss Alfatradiol as a weak estrogen and 5α-reductase inhibitor used for pattern hair loss in men and women.

community Pre Fin Bloodwork To Check Other Potential Issues

in Chat 22 upvotes 4 years ago

A user preparing to start finasteride for hair loss wanted to check for any abnormal bloodwork related to hair loss. They shared their blood test results and learned from another user that their doctor prescribed finasteride without any preliminary tests.

community My Estradiol Level on Finasteride

in Research/Science 19 upvotes 1 month ago

Finasteride has no effect on the user's estradiol levels, and body fat may influence aromatization. The user is on testosterone replacement therapy and uses everyday injections to manage high RBC count, with plans to measure DHT, DHEA-S, and pregnenolone levels.

community New warning by FDA on topical finasteride

in Research/Science 194 upvotes 3 months ago

The FDA warned that topical finasteride can cause serious side effects like sexual dysfunction and brain fog, similar to oral finasteride. Compounded topical formulations pose additional risks due to lack of regulation.

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