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H3K9me3 Methyltransferase SETDB1 Controls Retrotransposon Silencing, DNA Methylation, Constitutive Heterochromatin Maintenance and 3D-Chromatin Structure in Epidermal Keratinocytes

research H3K9me3 Methyltransferase SETDB1 Controls Retrotransposon Silencing, DNA Methylation, Constitutive Heterochromatin Maintenance and 3D-Chromatin Structure in Epidermal Keratinocytes

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

SETDB1 is essential for controlling DNA methylation, silencing retrotransposons, and maintaining skin cell health, with its absence leading to skin inflammation and hair loss.

research Establishment of Type II 5α-Reductase Over-Expressing Cell Line as an Inhibitor Screening Model

12 citations, June 2007 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

A reliable model for screening type II 5α-reductase inhibitors was created and validated.

research Predominant Expression of 5 Alpha-Reductase Type 1 in Pubic Skin from Normal Subjects and Hirsute Patients

11 citations, May 1996 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.

research Identification of Dkk4 as a Target of Eda-A1/Edar Pathway Reveals an Unexpected Role of Ectodysplasin as Inhibitor of Wnt Signaling in Ectodermal Placodes

117 citations, April 2008 in “Developmental biology”

Ectodysplasin inhibits Wnt signaling to help form hair follicles.

Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

research Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

402 citations, August 2011 in “Cancer research”

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

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community Why I believe alfatrodial and fluridil combined with minoxidil is an effective treatment. My experience.

in Research/Science 10 upvotes 3 months ago

The user believes that combining alfatrodial and fluridil with minoxidil effectively maintains hair, based on their 7-year experience. They suggest this combination for those who can't tolerate finasteride.

community DHT is about to get smashed ….

in Update 806 upvotes 2 months ago

The conversation discusses hair loss treatments like topical finasteride with minoxidil, oral dutasteride, and essential oils. Oral treatments like dutasteride and finasteride are seen as more effective, though some prefer topicals to avoid side effects.

community Hims Tropical tropical fin and min I have been using it for 4 months. Do you think it's working?

in Is this regrowth? 558 upvotes 1 year ago

The user is asking if the Hims Tropical tropical fin and min treatment is working for hair regrowth. Some users believe it is working, while others do not see a difference. The cost of the treatment is $195 for a 5 month supply.

community 2.5 months result after using minoxidil+finasteride on scalp

in Progress Pictures 183 upvotes 1 year ago

And minoxidil. This user posted progress pictures after using a combination of minoxidil and finasteride over a 2.5 month period, which received various comments from other users with differing opinions.

community 3 years of finasteride and minoxidil

in Progress Pictures 1256 upvotes 1 year ago

This conversation is about a user who used finasteride and minoxidil over the course of three years to treat their hair loss, and they achieved great results. They experienced severe shedding when first beginning treatment but eventually saw very noticeable results after one year.

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