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SETDB1 is essential for controlling DNA methylation, silencing retrotransposons, and maintaining skin cell health, with its absence leading to skin inflammation and hair loss.

A reliable model for screening type II 5α-reductase inhibitors was created and validated.

The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.

Ectodysplasin inhibits Wnt signaling to help form hair follicles.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

Certain inhibitors slow down plant growth by causing early cell specialization without changing the cell development pattern.

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.

Scientists found new, better-working inhibitors for a hormone-related enzyme.

Leflunomide and anthralin may effectively treat severe alopecia areata.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

PDE inhibitors, especially PDE4 inhibitors like apremilast, are effective for certain inflammatory skin conditions but have side effects and can be costly.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Antidepressants, 5α-reductase inhibitors, and isotretinoin can cause long-lasting sexual dysfunction.

Four new compounds were more effective than finasteride in treating prostate issues and hair loss, with one being 100 times more active and safe for use.

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

Chitosan-coated nanoparticles improve skin delivery of hair loss treatments with fewer side effects.

Some newly made compounds are promising for treating enlarged prostate, hair loss, viruses, and prostate cancer, and might be better than current drugs.

New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

Finasteride effectively treats hair loss and enlarged prostate in men, with mild side effects.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

Antidepressants called SSRIs can cause skin problems, bleeding risk, and other side effects.

Using finasteride or dutasteride does not increase the risk of male breast cancer.

A blood pressure drug, diltiazem, may also help treat influenza.

Semecarpus anacardium leaf extracts may offer safe, effective cancer treatment alternatives.

New compounds were made that effectively block enzymes related to prostate issues and hair loss.

New compounds were made that effectively block a specific enzyme related to androgen conditions.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.