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SETDB1 is essential for controlling DNA methylation, silencing retrotransposons, and maintaining skin cell health, with its absence leading to skin inflammation and hair loss.

Harlequin mutant mice have hair loss due to low AIF protein levels and retroviral element activity.

Lengthening telomeres may reverse aging and extend lifespan.

The environment around the time of conception can change the VTRNA2-1 gene in a way that lasts for years and may affect disease risk.

Controlling transposable elements is crucial for successful tissue regeneration.