learn Osteopontin
signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
Search
forResearch
5 / 1000+ resultsresearch Molecular Mediators Involved in Skin Healing: A Narrative Review
Understanding biological mediators in skin healing can improve treatments for skin wounds.
research Antioxidants and Long Covid
The conclusion suggests that managing antioxidant levels and the calcium to magnesium ratio may help address Long Covid and related chronic fatigue conditions.
research Secretome of Hypoxic Mesenchymal Stem Cells Improves Fluconazole-Induced Alopecia in Rats via Immunoregulatory Modulation of IL-15 and IFN-γ
A gel from stem cells can reduce baldness caused by fluconazole in rats.
research Plakophilin 1 Suppresses Keratinocyte Innate Immune Responses Through DExD/H Helicases
Plakophilin 1 (PKP1) plays a crucial role in regulating innate immune responses in keratinocytes by sequestering specific dsRNA sensing DExD/H-box RNA helicases, thereby limiting their activation of the MDA5-MAVS signaling axis. This action prevents excessive activation of transcription factors IRF3 and NFκB, reducing the transcription of proinflammatory cytokines like IFN-β1, IL6, and TNFα. Upon dsRNA challenge, PKP1 undergoes proteasomal degradation, releasing the helicases to enable a rapid inflammatory response. PKP1 thus balances epidermal immune homeostasis by providing a barrier against harmful substances and suppressing excessive immune responses, with its loss leading to conditions like ectodermal dysplasia-skin fragility syndrome (EDSFS).
research Inflammatory Priming Enhances Mesenchymal Stromal Cell Secretome Potential as a Clinical Product for Regenerative Medicine Approaches Through Secreted Factors and EV-miRNAs: The Example of Joint Disease
IFNγ-primed MSC secretomes can improve joint health by reducing inflammation and supporting tissue repair.
Community Join
3 / 3 results
community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment
The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.
community Verteporfin and Microneedling
Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.
community Fevipiprant 2019!
The conversation discusses Fevipiprant, an asthma drug that may block CRTH2 and potentially stop male pattern baldness (MPB) without inhibiting DHT. It also mentions the use of finasteride and dutasteride for hair loss.