July 2023 in “Current Issues in Molecular Biology” Escin may help treat hair loss by boosting a specific cell growth pathway.
7 citations
,
January 2023 in “Journal of Hematology & Oncology” Using protein degradation to fight cancer drug resistance shows promise but needs more precise targeting and fewer side effects.
Plakophilin 1 (PKP1) plays a crucial role in regulating innate immune responses in keratinocytes by sequestering specific dsRNA sensing DExD/H-box RNA helicases, thereby limiting their activation of the MDA5-MAVS signaling axis. This action prevents excessive activation of transcription factors IRF3 and NFκB, reducing the transcription of proinflammatory cytokines like IFN-β1, IL6, and TNFα. Upon dsRNA challenge, PKP1 undergoes proteasomal degradation, releasing the helicases to enable a rapid inflammatory response. PKP1 thus balances epidermal immune homeostasis by providing a barrier against harmful substances and suppressing excessive immune responses, with its loss leading to conditions like ectodermal dysplasia-skin fragility syndrome (EDSFS).
52 citations
,
May 2011 in “APOPTOSIS” Hydroxyl radicals cause hair follicle cell death during chemotherapy by reducing Bcl-2 protein levels.
15 citations
,
March 2015 in “Experimental Dermatology” Clotrimazole, an antifungal cream, may safely reduce skin pigmentation by breaking down the enzyme needed for making melanin.