144 citations,
November 2020 in “Frontiers in immunology” Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.
5 citations,
September 2021 in “Frontiers in Cell and Developmental Biology” Dihydrotestosterone treatment on 2D and 3D-cultured skin cells slows down hair growth by affecting certain genes and could be a potential target for hair loss treatment.
December 2022 in “Research Square (Research Square)” The study investigates gene expression in hair follicles affected by chronic discoid lupus erythematosus (CDLE) using bioinformatics methods. By analyzing data from 4 healthy and 7 CDLE-affected hair follicles, and validating with 13 healthy and 47 CDLE-affected scalp samples, the researchers identified key genes through differential expression and WGCNA. These genes, associated with type I interferon response and RIG-1 and IL-17 signaling pathways, were significantly upregulated in both hair follicles and skin tissues. The study also suggests the involvement of follicular helper T cells (Tfhs) in the disease process.
October 2022 in “Research Square (Research Square)” The study analyzed gene expression data from hair follicles affected by chronic discoid lupus erythematosus (CDLE) using bioinformatics methods. It identified key genes through differential gene expression analysis and weighted gene co-expression network analysis (WGCNA). The findings were validated with additional data from skin samples. The study found that type I interferon response-related genes, activated by the RIG-1 and IL-17 signaling pathways, were significantly up-regulated in CDLE-affected hair follicles and skin tissues. The involvement of follicular helper T cells (Tfhs) was also suggested in the disease process.
February 2023 in “Research Square (Research Square)” Blocking IL-17 can reduce skin inflammation in a mouse model of pityriasis rubra pilaris.