SnapshotDx Quiz: April 2022

March 2022 in “ Journal of Investigative Dermatology ”

Brandon Burroway, Deborah A. Lin, Mariya Miteva

TLDR Discoid Lupus Erythematosus causes scalp plaques that can lead to hair loss, and antimalarial drugs are effective treatments.

The document is a quiz from the Journal of Investigative Dermatology that focuses on diagnosing discoid lupus erythematosus (DLE) using clinical and dermatoscopic images. It highlights that DLE is characterized by erythematous plaques on the scalp leading to alopecic patches and discusses the role of IFN-1s in cutaneous lupus erythematosus (CLE) inflammation. The quiz emphasizes the effectiveness of antimalarial drugs in treating CLE and notes the low incidence (2-3%) of squamous cell carcinoma in DLE lesions. Additionally, it discusses the accumulation of senescent cells, marked by p16 and p21, in CLE lesions, particularly in chronic discoid lupus erythematosus (CDLE), which is linked to increased inflammation due to the secretion of proinflammatory cytokines and chemokines.

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