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4 / 4 resultslearn Cetirizine
popular antihistamine showing promise for hair loss as an anti-inflammatory and prostaglandin inhibitor
learn Tofacitinib
a JAK inhibitor for alopecia areata and other autoimmune conditions
learn Stemoxydine
chemical from L'Oreal that encourages hair to enter growth phase
Research
5 / 1000+ resultsresearch SnapshotDx Quiz: April 2022
The "SnapshotDx Quiz: April 2022" from the Journal of Investigative Dermatology focuses on diagnosing Discoid Lupus Erythematosus (DLE) and highlights that DLE manifests as erythematous plaques on the scalp, which can evolve into alopecic patches. Key findings include the role of IFN-1s in driving inflammation in all cutaneous lupus erythematosus (CLE) types, the presence of senescent cells marked by p16 and p21 in CLE lesions, and the upregulation of the Jak/STAT pathway in CLE. The quiz also notes that serologic abnormalities are uncommon in DLE, antimalarial drugs are effective in treating CLE, and the incidence of squamous cell carcinoma in DLE lesions is low (2-3%). The document suggests a link between inflammation and cellular senescence, with higher levels of p16+ and p21+ cells in more inflamed and chronic conditions.
research Evaluation of the Relationship Between Alopecia Areata and Viral Antigen Exposure
Hepatitis B virus exposure may be linked to increased risk of alopecia areata.
research Interferons in Dermatology
Interferons are effective for some skin conditions and cancers, but can have side effects and need more research for optimal use.
research The Effects of Androgens on T Cells: Clues to Female Predominance in Autoimmune Liver Diseases
Androgens may influence T cells, contributing to higher autoimmune liver disease risk in women.
research Protective Effects of Melatonin on the Skin: Future Perspectives
Melatonin, usually known for sleep regulation, also has antioxidant properties that can protect skin, stimulate hair growth, and improve skin conditions, with topical application being more effective than oral use.
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5 / 125 resultscommunity Peptides that Stop Hair Loss? | In-depth Literature Review Video
Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.
community 35 MtF | 16 Months | Minoxidil + Dutasteride + Microneedling + Exosomes. Note that since I'm early in my transition (and I was coming from a bald state), I still have short hair. Very few MtF progress pictures here, I figure this might help some of you.
A 35-year-old transitioning female (MtF) shared her hair regrowth journey using Minoxidil, Dutasteride, Microneedling, and Exosomes, starting from a bald state. Commenters discussed the impressive results, skin care routine, and the effects of estrogen on hair and skin.
community FCE 28260: A Forgotten 5α-Reductase Inhibitor
FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.
community For those of you who are getting facial skin side effects (aging, dark circles) from minoxidil, try this, it helped me.
The conversation provides tips to reduce facial skin side effects from Minoxidil, such as changing pillowcases, sleeping on the back, careful application, hydration, and taking breaks. One reply suggests that alcohol in Minoxidil formulations, not Minoxidil itself, may cause skin aging.
community Transient and Permanent Effects of Finasteride Use
Potential side effects of 5AR inhibitors like finasteride and dutasteride. Users debate risks, benefits, and personal experiences with these hair loss treatments.