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GlossaryPegylated Interferon

modified interferon with polyethylene glycol for prolonged therapeutic effect

Pegylated Interferon, often abbreviated as PEG-IFN, is a modified form of interferon used to treat certain viral infections and cancers. The "pegylation" process involves attaching polyethylene glycol (PEG) molecules to the interferon, which helps to prolong its presence in the bloodstream, reduce the frequency of dosing, and minimize side effects. This modification enhances the therapeutic efficacy and patient compliance compared to standard interferon treatments.

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research Pegylated-Interferon-Alpha 2a in Clinical Practice: How to Manage Patients Suffering from Side Effects

17 citations, February 2011 in “Expert Opinion on Drug Safety”

Manage side effects of hepatitis C treatment with dose changes and medications, which may improve patient adherence and treatment success.

research Vogt-Koyanagi-Harada Disease Occurring During Pegylated Interferon-α2b and Ribavirin Combination Therapy for Chronic Hepatitis C

17 citations, January 2011 in “The Korean Journal of Hepatology”

Vogt-Koyanagi-Harada disease can develop during interferon therapy for chronic hepatitis C.

research Predictive Factors for Adverse Dermatological Events During Pegylated/Interferon Alpha and Ribavirin Treatment for Hepatitis C

11 citations, April 2014 in “Journal of Clinical Virology”

Older age, pre-existing skin conditions, cirrhosis, and pegylated interferon use increase the risk of skin issues during hepatitis C treatment.

Exacerbation of Alopecia Areata During Pegylated Interferon Alpha-2b and Ribavirin Therapy, Possibly Due to the Collapse of Hair Follicle Immune Privilege

research Exacerbation of Alopecia Areata During Pegylated Interferon Alpha-2b and Ribavirin Therapy, Possibly Due to the Collapse of Hair Follicle Immune Privilege

10 citations, September 2014 in “European Journal of Dermatology”

A woman's hair loss worsened after starting hepatitis C treatment due to immune changes in her hair follicles.

Irreversible Alopecia Universalis During Treatment With Pegylated Interferon-Ribavirin for Chronic Hepatitis C Virus Infection: Case Report and Literature Review

research Irreversible Alopecia Universalis During Treatment With Pegylated Interferon-Ribavirin for Chronic Hepatitis C Virus Infection: Case Report and Literature Review

9 citations, November 2012 in “Hepatology Research”

A man lost all his hair permanently after hepatitis C treatment, a side effect not seen before.

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