Quercetin Nanocrystal Gel: A Novel Topical Therapeutic Strategy for Androgenetic Alopecia

    September 2025 in “ Pharmaceutics ”
    Y. J. Su, Yuwen Zhu, Lei Ren, Xiang Deng, Rui Song, Lingling Wu, Zhihui Yang, Hailong Yuan
    TLDR Quercetin nanocrystal gel shows promise for hair regrowth in androgenetic alopecia.
    The study investigates the development of a quercetin nanocrystal gel (QT-NC gel) as a novel topical treatment for androgenetic alopecia (AGA). By enhancing the transdermal delivery of quercetin, the QT-NC gel significantly improved skin penetration and retention compared to traditional formulations. In a dihydrotestosterone-induced AGA mouse model, the gel demonstrated significant hair regrowth, reduced DHT levels, and increased hair coverage and diameter, comparable to minoxidil. The combination of quercetin and glycyrrhizic acid showed synergistic effects, suggesting QT-NC gel as a promising therapeutic strategy for AGA with potential for clinical application. Further studies are needed to explore follicular targeting mechanisms and conduct clinical trials.
    Discuss this study in the Community →

    Research cited in this study

    21 / 21 results

    Related Community Posts Join

    6 / 42 results

      community Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia.

      in Research/Science  13 upvotes 1 year ago
      A quercetin-encapsulated and polydopamine-integrated nanosystem (PDA@QLipo) shows promise for treating androgenetic alopecia by reshaping the perifollicular microenvironment, outperforming minoxidil in hair regeneration. The nanosystem promotes cell proliferation, hair follicle renewal, and recovery by scavenging reactive oxygen species and enhancing neovascularity.

      community what do you think about Ell-Cranell + Quercetin

      in Treatment  6 upvotes 2 years ago
      The post discusses the use of El-Cranell, which contains Alfatradiol, and Quercetin as a treatment for hair loss. The user is seeking recommendations on the amount of Quercetin to add to the solution. The conclusion of the document is that Quercetin has been shown to stimulate hair growth and inhibit DHT, and combining it with zinc/copper may have a synergistic effect.

      community Male Pattern Baldness Routine

      in Ketoconazole  7 upvotes 4 years ago
      An 18-year-old diagnosed with male pattern baldness is using probiotics, saw palmetto, pumpkin seed oil, soy isoflavones, biotin, fish oil, quercetin, a multivitamin, and ketoconazole shampoo. Replies suggest these methods are ineffective and recommend finasteride, minoxidil, and a derma roller.

      community anything to add to my regime?

      in Advice 5 years ago
      The conversation is about a hair loss treatment regimen that includes finasteride, dutasteride, oral minoxidil, Dermapen, quercetin, N-acetyl L-cysteine, biotin, millet seed extract, MSM, OPC, green tea extract, high-dose vitamins B1-B12, boron, and silica. The user is seeking advice on additional treatments.

    Similar Research

    5 / 590 results