The Preparation of High Minoxidil Loaded Transfersomes and Its Gel for Effective Topical Treatment of Alopecia

    April 2023 in “ Journal of Drug Delivery Science and Technology ”
    Ying Sun, Yongxiang Zhang, Xiaxia Liu, Yan Tingting, Liyan Shen, Dan Ye, Xia Kong, Yonghui Su, Qingping Tian
    TLDR The new minoxidil gel improves hair growth and reduces skin irritation.
    The study aimed to design a transfersomal formulation of minoxidil (MXD) with high drug content (DC) and entrapment efficiency (EE) to improve hair growth and reduce skin irritation for the treatment of alopecia. By using Tween 80 as an edge activator and the thin film hydration method, the researchers significantly improved the DC and EE of MXD transfersomes. The optimized transfersomes and their gel form had a spherical morphology, no aggregation, and a particle size of less than 100 nm. This formulation showed enhanced skin permeability, stability, and hair regeneration effects with minimal skin irritation.
    Discuss this study in the Community →

    Research cited in this study

    27 / 27 results

    Related Community Posts Join

    6 / 1000+ results

      community Scared of Twink death due to minoxidil

      in Minoxidil 1 week ago
      A 19-year-old is considering switching from topical to oral minoxidil to combat hair loss, despite concerns about increased body hair. They are currently using minoxidil, ketoconazole shampoo, and dutasteride, and are willing to accept the trade-off of more body hair for better scalp hair growth.

      community Foam minoxidil with Tretinoin (Which Tretinoin Strength?)

      in Minoxidil  2 upvotes 1 week ago
      The conversation discusses using foam minoxidil with tretinoin cream for hair loss, with users sharing experiences on tretinoin strengths of 0.025% and 0.05%. Some users report irritation with higher tretinoin concentrations and note that foam minoxidil may be less effective than liquid.

      community 3,5 months of only topical minoxidil

      in Minoxidil  762 upvotes 1 week ago
      A 24-year-old reported new hair growth on temples after 3.5 months of using topical minoxidil without shedding. They plan to add finasteride to maintain progress, as minoxidil alone may not be enough long-term.

    Related Research

    8 / 8 results